| Autor: |
Petry NJ; Sanford Health Imagenetics, 1321 W 22nd St, Sioux Falls, SD 57105, USA.; Department of Pharmacy Practice, North Dakota State University, Fargo, ND 58108, USA., Baye JF; Sanford Health Imagenetics, 1321 W 22nd St, Sioux Falls, SD 57105, USA.; South Dakota State University, College of Pharmacy & Allied Health Professions, SD 57007, USA.; University of South Dakota, Department of Internal Medicine, SD 57105, USA., Frear S; Sanford Health Imagenetics, 1321 W 22nd St, Sioux Falls, SD 57105, USA., Jacobsen K; Sanford Health Imagenetics, 1321 W 22nd St, Sioux Falls, SD 57105, USA., Massmann A; Sanford Health Imagenetics, 1321 W 22nd St, Sioux Falls, SD 57105, USA.; University of South Dakota, Department of Internal Medicine, SD 57105, USA., Schultz A; Sanford Health Imagenetics, 1321 W 22nd St, Sioux Falls, SD 57105, USA.; University of South Dakota, Department of Internal Medicine, SD 57105, USA., Heukelom JV; Sanford Health Imagenetics, 1321 W 22nd St, Sioux Falls, SD 57105, USA.; University of South Dakota, Department of Internal Medicine, SD 57105, USA., Christensen K; Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.; Department of Population Medicine, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA. |
| Abstrakt: |
Background: Statins are among the most commonly prescribed medications, and improve patient outcomes by lowering cholesterol levels, but also have side effects. Variations in statin response can be attributed to a handful of factors that include pharmacogenetics. Methods: While not a true review article, this work was written using various search engines and terms and previous and newly published Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for statins to provide a historical perspective in addition to the current status of statin-related pharmacogenetics and future perspectives. Results: This article provides historical background on statins and associated adverse effects, reviews pharmacogenetic implications, applies clinical decision support, incorporates the latest CPIC guidelines and addresses future implications. Conclusion: Statins are a beneficial medication, but not without risk. Pharmacogenomics can help mitigate some risk factors. Clinical decision support, implementation, research and guidelines will continue to influence statin prescribing. |
