Incidence of SARS-CoV-2 reinfection in a paediatric cohort in Kuwait.

Autor:	Alhaddad F; Department of Pediatrics, Farwaniya Hospital, Farwaniya, Kuwait., Abdulkareem A; Department of Pediatrics, Farwaniya Hospital, Farwaniya, Kuwait., Alsharrah D; Department of Pediatrics, Farwaniya Hospital, Farwaniya, Kuwait., Alkandari A; Department of Population Health, Dasman Diabetes Institute, Kuwait City, Kuwait., Bin-Hasan S; Department of Pediatrics, Farwaniya Hospital, Farwaniya, Kuwait.; Department of Population Health, Dasman Diabetes Institute, Kuwait City, Kuwait., Al-Ahmad M; Department of Microbiology, Kuwait University Faculty of Medicine, Safat, Al Asimah, Kuwait., Al Hashemi H; Department of Pediatrics, Farwaniya Hospital, Farwaniya, Kuwait., Alghounaim M; Department of Pediatrics, Amiri Hospital, Kuwait City, Kuwait malghounaim@moh.gov.kw.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Jun 28; Vol. 12 (6), pp. e056371. Date of Electronic Publication: 2022 Jun 28.
DOI:	10.1136/bmjopen-2021-056371
Abstrakt:	Objective: Subsequent protection from SARS-CoV-2 infection in paediatrics is not well reported in the literature. We aimed to describe the clinical characteristics and dynamics of SARS-CoV-2 PCR repositivity in children. Design: This is a population-level retrospective cohort study. Setting: Patients were identified through multiple national-level electronic COVID-19 databases that cover all primary, secondary and tertiary centres in Kuwait. Participants: The study included children 12 years and younger between 28 February 2020 and 6 March 2021. SARS-CoV-2 reinfection was defined as having two or more positive SARS-CoV-2 PCR tests done on a respiratory sample, at least 45 days apart. Clinical data were obtained from the Pediatric COVID-19 Registry in Kuwait. Primary and Secondary Outcome Measures: The primary measure is to estimate SARS-CoV-2 PCR repositivity rate. The secondary objective was to establish average duration between first and subsequent SARS-CoV-2 infection. Descriptive statistics were used to present clinical data for each infection episode. Also, incidence-sensitivity analysis was performed to evaluate 60-day and 90-day PCR repositivity intervals. Results: Thirty paediatric patients with COVID-19 had SARS-CoV-2 reinfection at an incidence of 1.02 (95% CI 0.71 to 1.45) infection per 100 000 person-days and a median time to reinfection of 83 (IQR 62-128.75) days. The incidence of reinfection decreased to 0.78 (95% CI 0.52 to 1.17) and 0.47 (95% CI 0.28 to 0.79) per person-day when the minimum interval between PCR repositivity was increased to 60 and 90 days, respectively. The mean age of reinfected subjects was 8.5 (IQR 3.7-10.3) years and the majority (70%) were girls. Most children (55.2%) had asymptomatic reinfection. Fever was the most common presentation in symptomatic patients. One immunocompromised experienced two reinfection episodes. Conclusion: SARS-CoV-2 reinfection is uncommon in children. Previous confirmed COVID-19 in children seems to result in a milder reinfection. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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