Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder: Evidence from GROUP, a longitudinal study.

Autor: Burin LM; Center of Clinical Research and Center of Experimental Research, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil; Post-Graduation Program in Psychiatry and Behavioral Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; I-QOL Innovations and Interventions for Quality of Life research group, Porto Alegre, Brazil. Electronic address: luisaburin@gmail.com., Hahn MK; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting and Best Diabetes Centre (BBDC), University of Toronto, Toronto, ON, Canada., da Rocha NS; Center of Clinical Research and Center of Experimental Research, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil; Post-Graduation Program in Psychiatry and Behavioral Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; I-QOL Innovations and Interventions for Quality of Life research group, Porto Alegre, Brazil; Psychiatry Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil., van Amelsvoort T; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands., Bartels-Velthuis AA; Department of Psychiatry & Rob Giel Research Center, University Medical Centre Groningen, University of Groningen, the Netherlands., Bruggeman R; Department of Psychiatry & Rob Giel Research Center, University Medical Centre Groningen, University of Groningen, the Netherlands; Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, the Netherlands., de Haan L; Department of Psychiatry, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands; Arkin, Institute for Mental Health, Amsterdam, the Netherlands., Schirmbeck F; Department of Psychiatry, Academic Medical Centre University of Amsterdam, Amsterdam, the Netherlands; Arkin, Institute for Mental Health, Amsterdam, the Netherlands., Simons CJP; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands; GGzE Institute for Mental Health Care, Eindhoven, the Netherlands., van Os J; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Psychosis Studies, Institute of Psychiatry, King's College London, King's Health Partners, London, United Kingdom., Cahn W; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands; Altrecht, General Mental Health Care, Utrecht, the Netherlands.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2022 Aug; Vol. 314, pp. 114680. Date of Electronic Publication: 2022 Jun 12.
DOI: 10.1016/j.psychres.2022.114680
Abstrakt: Introduction: Antipsychotics (APs) can cause weight gain. Little is known about changes in weight when APs are combined with other psychotropics. This study examines the weight change in patients undergoing long-term treatment with APs or with AP combined with other psychotropics.
Methods: Patients with non-affective psychotic disorder from the GROUP study were divided into three groups: AP medication group (APm) (n = 100), AP in combination with other psychotropics (APc) (n = 73), and medication-free (Meds-free) (n = 100). Weight change was examined at inclusion and after three years using a paired-sample t-test. An Independent-sample t-test was performed to evaluate weight change among patients taking clozapine, olanzapine, and quetiapine and individuals not taking these medications. Linear regression was performed to evaluate the association between covariates and weight.
Results: Patients in the APm group [mean = 1.800 kg, t(99)=2.849, 95% CI(0.546, 3.054), p = 0.005] and the APc group [mean = 1.877 kg, t(72)=2.688, 95% CI(0.485, 3.268), p = 0.009] showed significant weight gain. Patients taking clozapine, olanzapine or quetiapine showed significant weight gain compared to those not taking these medications [mean difference=1.707 kg, t(271)= 2.061, 95% CI(0.077, 3.337), p = 0.040)].
Conclusion: Patients receiving APs and APs with other psychotropics gain weight during long-term treatment. It is possible that weight gain is mainly driven by APs.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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