Molecular and clinical characteristics of carbapenem-resistant Enterobacteriaceae isolates collected at a tertiary hospital in northern China.

Autor:	Wang H; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.; Department of Parasitology, the School of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot 010050, China., Yan Z; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.; Department of Parasitology, the School of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot 010050, China., Mu L; Department of Parasitology, the School of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot 010050, China., Gao XY; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.; Inner Mongolia Key Laboratory of Clinical Pathogenic Microorganism, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China., Li JY; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China., Hu ZD; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China., Wang JR; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.; Inner Mongolia Key Laboratory of Clinical Pathogenic Microorganism, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China., Zheng WQ; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.; Department of Parasitology, the School of Basic Medical Sciences of Inner Mongolia Medical University, Hohhot 010050, China.; Inner Mongolia Key Laboratory of Clinical Pathogenic Microorganism, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Jazyk:	angličtina
Zdroj:	Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2023 Jan 03; Vol. 117 (1), pp. 55-57.
DOI:	10.1093/trstmh/trac059
Abstrakt:	Background: Carbapenem-resistant Enterobacteriaceae (CRE) represent a severe public health problem. Methods: In a tertiary hospital in northern China, 169 non-duplicated clinical CRE strains were analyzed by species identification, in vitro antibiotics sensitivity test, carbapenemase gene detection and genetic sequence typing. Results: The CRE strains showed high resistance to most clinical antimicrobials. Enterobacter cloacae and Escherichia coli isolates mainly carried blaNDM, and Klebsiella pneumoniae isolates mainly carried blakpc. ST11 was the most common type in Klebsiella pneumoniae, and ST70 was the new emerging sequence type (ST) in Enterobacter cloacae. Conclusions: The CRE strains isolated in northern China showed multidrug-resistant phenotypes, and the new emergence of ST70 Enterobacter cloacae should be closely supervised. (© The Author(s) 2022. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
Databáze:	MEDLINE
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