Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients.

Autor: Tekin SS; Department of Medical Biology, Mersin University Faculty of Medicine, Mersin, Turkey., Erdal ME; Department of Medical Biology, Mersin University Faculty of Medicine, Mersin, Turkey., Asoğlu M; Department of Psychiatry, Harran University Faculty of Medicine, Şanlıurfa, Turkey., Ay Öİ; Department of Medical Biology, Mersin University Faculty of Medicine, Mersin, Turkey., Ay ME; Department of Medical Biology, Mersin University Faculty of Medicine, Mersin, Turkey., Yılmaz ŞG; Department of Nutrition and Dietetics, Gaziantep University Faculty of Health Science, Gaziantep, Turkey.
Jazyk: angličtina
Zdroj: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2022 Jun 24; Vol. 40 (44), pp. 378-387. Date of Electronic Publication: 2022 Jun 24.
DOI: 10.47626/1516-4446-2021-2260
Abstrakt: Objective: Bipolar I disorder (BD-I) is a type of bipolar spectrum disorder characterized by manic or mixed episodes. Detecting microRNA regulations as epigenetic actors in BD-I is important to elucidate the pathogenesis of the disease and reveal the potential of microRNAs (miRNAs) as biomarkers.
Methods: We evaluated the expression profile of six candidate miRNAs (hsa-miR-145-5p, hsa-miR-376a-3p, hsa-miR-3680-5p, hsa-miR-4253-5p, hsa-miR-4482-3p, and hsa-miR-4725) in patients with BD-I and in healthy controls (aged 11-50 years). We also determined the potential target genes of these miRNAs through in silico analysis. The diagnostic values of the miRNAs were calculated through receiver operating characteristic curve analysis.
Results: Four miRNAs were upregulated (hsa-miR-376a-3p, hsa-miR-3680-5p, hsa-miR-4253-5p, hsa-miR-4482-3p) and hsa-miR-145-5p was downregulated in patients (p < 0.001). The target gene analyses showed that hsa-miR-145-5p specifically targets the dopamine decarboxylase (DDC) gene. The area under the curve of hsa-miR-145-5p was 0.987.
Conclusion: Differential expression of five miRNAs in peripheral blood may be associated with the pathogenesis of BD-I, and hsa-miR-145-5p has potential as a BD-I biomarker. This miRNA can be used in dopamine-serotonin regulation and dose adjustment in drug therapy via the DDC gene.
Competing Interests: The authors report no conflicts of interest.
Databáze: MEDLINE
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