Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age.

Autor:	Ferrara F; Heart Department, University Hospital of Salerno, 84131 Salerno, Italy., Capone V; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy.; Department of Advanced Biomedical Sciences, 'Federico II' University of Naples, 80131 Naples, Italy., Cademartiri F; Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy., Vriz O; Echocardiography Department, Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia., Cocchia R; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Ranieri B; IRCCS SYNLAB SDN, Via Emanuele Gianturco, 113-80143 Naples, Italy., Franzese M; IRCCS SYNLAB SDN, Via Emanuele Gianturco, 113-80143 Naples, Italy., Castaldo R; IRCCS SYNLAB SDN, Via Emanuele Gianturco, 113-80143 Naples, Italy., D'Andrea A; Department of Cardiology and Intensive Coronary Unit, 'Umberto I' Hospital, 84014 Nocera Inferiore, Italy., Citro R; Heart Department, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84125 Salerno, Italy., Chianese S; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Annunziata R; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Marullo F; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Siniscalchi M; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Conte M; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Sepe C; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Maramaldi R; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Rega S; Department of Translational Medical Sciences, Federico II University, 80131 Naples, Italy., Russo G; Health Management Office, Antonio Cardarelli Hospital, 80131 Naples, Italy., Majolo M; Health Management Office, Antonio Cardarelli Hospital, 80131 Naples, Italy., Raiola E; Health Management Office, Antonio Cardarelli Hospital, 80131 Naples, Italy., Salzano A; IRCCS SYNLAB SDN, Via Emanuele Gianturco, 113-80143 Naples, Italy., Mauro C; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy., Trimarco B; Department of Advanced Biomedical Sciences, 'Federico II' University of Naples, 80131 Naples, Italy., Izzo R; Department of Advanced Biomedical Sciences, 'Federico II' University of Naples, 80131 Naples, Italy., Bossone E; Division of Cardiology, A Cardarelli Hospital, 80131 Naples, Italy.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2022 Jun 18; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 18.
DOI:	10.3390/jpm12060996
Abstrakt:	Background: Myocardial mechano-energetic efficiency (MEE) is the capability of the left ventricle (LV) to convert the chemical energy obtained from the cardiac oxidative metabolism into mechanical work. The aim of present study was to establish normal non-invasive MEE and MEEi reference values. Methods: In total, 1168 healthy subjects underwent physical examinations, clinical assessment, and standardized transthoracic echocardiographic (TTE) examination. MEE was obtained by TTE as the ratio between stroke volume (SV) and heart rate (HR): MEE = SV/HR [HR expressed in seconds (HR/60)]. Because MEE is highly related to left ventricular mass (LVM), MEE was then divided by LVM with the purpose of obtaining an estimate of energetic expenditure per unit of myocardial mass (i.e., indexed MEE, MEEi, mL/s/g). Results: The mean values of MEE and MEEi in the overall population were 61.09 ± 18.19 mL/s; 0.45 ± 0.14, respectively. In a multivariable analysis, gender, body surface area (BSA), diastolic blood pressure, left atrial volume indexed to BSA, E/e' and tricuspid annular plane systolic excursion (TAPSE) were the independent variables associated with MEE, while age, gender, BSA and TAPSE were the independent variables associated with MEEi. Conclusions: The knowledge of age- and gender-based MEE and MEEi normal values may improve the global assessment of LV cardiac mechanics and serve as a reference to identify phenotypes at high risk of cardiovascular events.
Databáze:	MEDLINE
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