Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse.

Autor: Rossato DR; Graduation Program in Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil., Rosa HZ; Graduation Program in Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil., Rosa JLO; Graduation Program in Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil., Milanesi LH; Department of Physiology and Pharmacology (UFSM), Santa Maria, Rio Grande do Sul, Brazil., Metz VG; Graduation Program in Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil., D'Àvila LF; Graduation Program in Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil., Burger ME; Graduation Program in Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil. marilise.burger@ufsm.br.; Department of Physiology and Pharmacology (UFSM), Santa Maria, Rio Grande do Sul, Brazil. marilise.burger@ufsm.br.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2022 Sep; Vol. 59 (9), pp. 5564-5573. Date of Electronic Publication: 2022 Jun 22.
DOI: 10.1007/s12035-022-02927-y
Abstrakt: Amphetamine (AMPH) is a psychostimulant drug frequently related to addiction, which is characterized by functional and molecular changes in the brain reward system, favoring relapse development, and pharmacotherapies have shown low effectiveness. Considering the beneficial influences of tactile stimulation (TS) in different diseases that affect the central nervous system (CNS), here we evaluated if TS applied in adult rats could prevent or minimize the AMPH-relapse behavior also accessing molecular neuroadaptations in the nucleus accumbens (NAc). Following AMPH conditioning in the conditioned place preference (CPP) paradigm, male rats were submitted to TS (15-min session, 3 times a day, for 8 days) during the drug abstinence period, which were re-exposed to the drug in the CPP paradigm for additional 3 days for relapse observation and molecular assessment. Our findings showed that besides AMPH relapse, TS prevented the dopamine transporter (DAT), dopamine 1 receptor (D1R), tyrosine hydroxylase (TH), mu opioid receptor (MOR) increase, and AMPH-induced delta FosB (ΔFosB). Based on these outcomes, we propose TS as a useful tool to treat psychostimulant addiction, which is subsequent to clinical studies; it could be included in detoxification programs together with pharmacotherapies and psychological treatments already conventionally established.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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