Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage.

Autor: de Araújo Andrade T; Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil. tatianny_aa@hotmail.com., Heimfarth L; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil., Dos Santos DM; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil.; Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brasil., Dos Santos MRV; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil.; Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brasil., de Albuquerque-Júnior RLC; Instituto de Tecnologia e Pesquisa-ITP, Universidade Tiradentes, Aracaju, Brasil., Dos Santos-Neto AG; Instituto de Tecnologia e Pesquisa-ITP, Universidade Tiradentes, Aracaju, Brasil., de Araujo GRS; Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil., Lira AAM; Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil., Matos SS; Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil., Frank LA; Programa de Pós-Graduação Em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brasil. luiza.frank@ufrgs.br., Rabelo TK; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada., Quintans-Júnior LJ; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil.; Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brasil., de Souza Siqueira Quintans J; Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil.; Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brasil., de Souza Araujo AA; Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil.; Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brasil., Serafini MR; Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brasil. maiserafini@hotmail.com.; Health Sciences Graduate Program, Universidade Federal de Sergipe, Aracaju, Sergipe, Brasil. maiserafini@hotmail.com.
Jazyk: angličtina
Zdroj: AAPS PharmSciTech [AAPS PharmSciTech] 2022 Jun 21; Vol. 23 (6), pp. 170. Date of Electronic Publication: 2022 Jun 21.
DOI: 10.1208/s12249-022-02323-8
Abstrakt: UV radiation can cause damages, such as erythema, skin photoaging, and carcinogenesis. The adoption of protective measures against sun exposure is essential to prevent these damages, and the interest in using natural substances as an alternative for photoprotection is growing. Thus, hesperetin with antioxidant, anti-inflammatory, and anticancer properties is a promising substance to be used with photochemopreventive action and to protect the skin from damage induced by UV radiation. Therefore, the present study aimed to develop a topical formulation based on AAMVPC gel containing hesperetin and evaluate its photoprotective effect on the skin of rats exposed to UVA-UVB radiation. The animals were submitted to the irradiation protocol UVA-UVB, and at the end, erythema, lipid peroxidation, and activity of the antioxidant enzyme catalase and superoxide dismutase were evaluated. Additionally, it evaluated the activity of myeloperoxidase and histological changes. The formulation presented a rheological and spreadability profile suitable for cutaneous application. In vivo results demonstrated that the topical formulation of AAMVPC gel containing hesperetin at a concentration of 10% protected the skin from damage induced by UVA-UVB radiation, with the absence of erythema, lipid lipoperoxidation, and inflammation (low myeloperoxidase activity), and increased catalase and superoxide dismutase activities. The morphology and architecture of the dermo-epidermal tissue of these animals were like those observed under normal conditions (non-irradiated animals). Thus, the results showed that hesperetin was able to protect the animals' skin against UV radiation-induced skin damage and the protection mechanisms may be related to the antioxidant and anti-inflammatory properties of this natural product.
(© 2022. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
Databáze: MEDLINE
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