Femoral Skeletal Perfusion is Reduced in Male Mice with Type 1 Diabetes.

Autor: Ucer Ozgurel S; Department of Anatomy, Cell Biology, and Physiology, School of Medicine, Indiana University, Indianapolis, IN, USA. sucerozgurel@austin.utexas.edu.; Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA. sucerozgurel@austin.utexas.edu., Swallow EA; Department of Anatomy, Cell Biology, and Physiology, School of Medicine, Indiana University, Indianapolis, IN, USA., Metzger CE; Department of Anatomy, Cell Biology, and Physiology, School of Medicine, Indiana University, Indianapolis, IN, USA., Allen MR; Department of Anatomy, Cell Biology, and Physiology, School of Medicine, Indiana University, Indianapolis, IN, USA.; Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA.; Department of Medicine - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biomedical Engineering, Indiana University Purdue University of Indianapolis, Indianapolis, IN, USA.
Jazyk: angličtina
Zdroj: Calcified tissue international [Calcif Tissue Int] 2022 Sep; Vol. 111 (3), pp. 323-330. Date of Electronic Publication: 2022 Jun 15.
DOI: 10.1007/s00223-022-00992-y
Abstrakt: The bone vasculature and blood flow are critical for bone modeling, remodeling, and regeneration. Vascular complications are one of the major health concerns of people with type 1 diabetes (T1D). Moreover, people with T1D have lower bone mineral density and increased bone fragility. The goal of this study was to understand whether bone perfusion was altered in a mouse model of T1D and how this related to changes in bone mass. T1D was induced via the administration of streptozotocin in 12-week-old C57BL/6NHsd male mice. The assessment of bone perfusion utilized the injection of fluorescent microspheres with assessment of levels in the bone. Femoral blood flow and VEGF-A expression in the cortical bone shafts were lower in the T1D mice, compared to healthy controls, in this pattern followed that of changes in bone mass. These data demonstrate a possible association between reduced skeletal perfusion and reduced bone mass in the setting of T1D.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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