A cross-sectional multicenter linkage study of hospital admissions and mortality due to methanol poisoning in Iranian adults during the COVID-19 pandemic.

Autor: Mahdavi SA; Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran., Zamani N; Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., McDonald R; SERAF, Norwegian Centre for Addiction Research, University of Oslo, Oslo, Norway., Akhgari M; Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran., Kolahi AA; Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Gheshlaghi F; Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Ostadi A; Department of Internal Medicine, Sina Medical Research & Training Hospital, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Dehghan A; Accident Prevention and Crisis Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran., Moshiri M; Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Rahbar-Taramsari M; Department of Forensic Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Delirrad M; Department of Forensic Medicine, School of Medicine, Food and Beverages Safety Research Center, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran., Mohtasham N; Department of Pediatric Clinical Toxicology, Abuzar's Children Medical Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Afzali S; Department of Forensic Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Ebrahimi S; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ziaeefar P; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Khosravi N; Department of Emergency Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Kazemifar AM; Department of Internal Medicine, Qazvin University of Medical Sciences, Qazvin, Iran., Ghadirzadeh M; Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran., Farajidana H; Department of Emergency Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran., Barghemadi T; Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Sadeghi F; Clinical Development Research Unit, Seyad Shirazi Hospital, Golestan University of Medial Sciences, Gorgan, Iran., Hadeiy SK; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hadipourzadeh M; Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mesbahi J; Qom University of Medial Sciences, Qom, Iran., Malekpour MR; Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Arabi M; Department of Family Medicine, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran., Jamshidi F; Department of Forensic Medicine and Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Dadpour B; Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Hovda KE; The Norwegian CBRNE Centre of Medicine, Department of Acute Medicine, Oslo University Hospital, Oslo, Norway., Hassanian-Moghaddam H; Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. hassanian@sbmu.ac.ir.; Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. hassanian@sbmu.ac.ir.; Loghman-Hakim Hospital Poison Center, South Karegar Street, Kamali St, Tehran, Iran. hassanian@sbmu.ac.ir.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jun 13; Vol. 12 (1), pp. 9741. Date of Electronic Publication: 2022 Jun 13.
DOI: 10.1038/s41598-022-14007-1
Abstrakt: A methanol poisoning outbreak occurred in Iran during the initial months of coronavirus disease 2019 (COVID-19) pandemic. We aimed to evaluate the epidemiology of the outbreak in terms of hospitalizations and deaths. A cross-sectional linkage study was conducted based on the hospitalization data collected from thirteen referral toxicology centers throughout Iran as well as mortality data obtained from the Iranian Legal Medicine Organization (LMO). Patient data were extracted for all cases aged > 19 years with toxic alcohol poisoning during the study period from February until June 2020. A total of 795 patients were hospitalized due to methanol poisoning, of whom 84 died. Median [interquartile ratio; IQR] age was 32 [26, 40] years (range 19-91 years). Patients had generally ingested alcohol for recreational motives (653, 82.1%) while 3.1% (n = 25) had consumed alcohol-based hand sanitizers to prevent or cure COVID-19 infection. Age was significantly lower in survivors than in non-survivors (P < 0.001) and in patients without sequelae vs. with sequelae (P = 0.026). Twenty non-survivors presented with a Glasgow Coma Scale (GCS) score > 8, six of whom were completely alert on presentation to the emergency departments. The time from alcohol ingestion to hospital admission was not significantly different between provinces. In East Azerbaijan province, where hemodialysis was started within on average 60 min of admission, the rate of sequelae was 11.4% (compared to 19.6% average of other provinces)-equivalent to a reduction of the odds of sequelae by 2.1 times [95% CI 1.2, 3.7; p = 0.009]. Older patients were more prone to fatal outcome and sequelae, including visual disturbances. Early arrival at the hospital can facilitate timely diagnosis and treatment and may reduce long-term morbidity from methanol poisoning. Our data thus suggest the importance of raising public awareness of the risks and early symptoms of methanol intoxication.
(© 2022. The Author(s).)
Databáze: MEDLINE
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