Nondirected Living Kidney Donation and Recipient Outcomes in the United States: A 20-Year Review.

Autor:	Jan MY; Division of Nephrology and Transplantation, Indiana University School of Medicine, Indianapolis, Indiana, USA., Yaqub MS; Division of Nephrology and Transplantation, Indiana University School of Medicine, Indianapolis, Indiana, USA., Adebiyi OO; Division of Nephrology and Transplantation, Indiana University School of Medicine, Indianapolis, Indiana, USA., Taber TE; Division of Nephrology and Transplantation, Indiana University School of Medicine, Indianapolis, Indiana, USA., Anderson MD; Division of Nephrology and Transplantation, Indiana University School of Medicine, Indianapolis, Indiana, USA., Mishler DP; Division of Nephrology and Transplantation, Indiana University School of Medicine, Indianapolis, Indiana, USA., Burney HN; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA., Li Y; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA., Li X; Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA., Sharfuddin AA; Division of Nephrology and Transplantation, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jazyk:	angličtina
Zdroj:	Kidney international reports [Kidney Int Rep] 2022 Mar 22; Vol. 7 (6), pp. 1289-1305. Date of Electronic Publication: 2022 Mar 22 (Print Publication: 2022).
DOI:	10.1016/j.ekir.2022.03.012
Abstrakt:	Introduction: Nondirected donation (NDD) of the kidneys is a growing practice where donors who do not have any genetic or emotional relationship are selected to donate to a wide variety of recipients with a range of selection criteria and decisions which are left up to individual transplant centers. Methods: We review all adult living kidney donor-recipient (DR) pairs and outcomes from NDDs who were recorded in United Network for Organ Sharing (UNOS) database as code 10 (anonymous) from October 1997 to September 2017 for demographics and outcomes. Results: A total of 2174 DR pairs were identified. The number of NDDs increased from 18 in 2000 to 256 in 2016. Survival analysis showed higher death-censored-graft survival (DC-GS) when recipient was 20 years or more older than donor followed by recipient-donor within 20 years of age and lowest when donor was 20 years or more older than recipient ( P  = 0.0114). Conclusion: Overall, the number of NDDs has increased significantly in the 20-year review period. Transplants from NDDs have excellent long-term outcomes. Better matching of controllable DR factors, such as age and body mass index (BMI), could further improve GS. Further research is needed to incorporate these DR factors into paired kidney donation programs potentially enhancing the utility and beneficence of this invaluable donation. (© 2022 Published by Elsevier, Inc., on behalf of the International Society of Nephrology.)
Databáze:	MEDLINE
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