Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats.
| Autor: | Ratnaningtyas NI; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Hernayanti H; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Ekowati N; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Husen F; Department of Medical Laboratory of Technology, Bina Cipta Husada College of Health Science, Central Java, Indonesia. |
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| Jazyk: | angličtina |
| Zdroj: | Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 1126-1136. |
| DOI: | 10.1080/13880209.2022.2074054 |
| Abstrakt: | Context: Edible mushrooms have a long history of use in traditional Chinese or Japanese medicine. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) contains antioxidant and antidiabetic agents. Objective: To identify the benefits of ethanol extracts of the C. comatus fruit body in streptozotocin-induced hyperglycaemic rats by evaluating their blood glucose, glycosylated haemoglobin (HbA1c), insulin, glucagon-like peptide-1 (GLP-1), dipeptidyl peptidase-4 (DPP-4), and glutathione (GSH) levels, with and without extract administration. Materials and Methods: Wistar rats were either left untreated or were administered 45 mg/kg body weight (BW) streptozotocin; 45 mg/kg BW metformin; or 250, 500, or 750 mg/kg BW extract for 14 days. The blood glucose, GLP-1, DPP-4, GSH, insulin, and HbA1c levels were determined. Data were analysed using analysis of variance and Duncan's multiple range tests. Results: Preliminary data showed that administration of C. comatus ethanol extract dose of 250, 500, and 750 mg orally has no toxicity effects after 24 h administration. The ethanolic extract of fruiting body of C. comatus considerably reduced the rat's fasting blood glucose levels 26.69%, and DPP-4 6.97% at dose of 750 mg. The extract reduced HbA1c 4-4.30%, increased GLP-1 71.09%, GSH 11.19% at dose of 500 mg, and increased insulin levels 13.83%. Extracts contain bioactive compounds such as flavonoid, alkaloid, terpenoids, vitamins C and E, rutin, and saponin. Conclusions: The C. comatus extract can be used as herbal medicine that reduces diabetic symptoms. Further investigation on C. comatus extracts should be conducted with gas chromatography-mass spectrometry to characterise the bioactive compounds. |
| Databáze: | MEDLINE |
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