Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum.

Autor: Lao P; Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Zimmerman ME; Department of Psychology, Fordham University, Bronx, NY 10458, USA., Hartley SL; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53706, USA., Gutierrez J; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Keator D; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA., Igwe KC; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Laing KK; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Cotton-Samuel D; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Sathishkumar M; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA., Moni F; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Andrews H; Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Krinsky-McHale S; Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Head E; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA., Lee JH; Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Lai F; Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA., Yassa MA; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USA., Diana Rosas H; Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA., Silverman W; Department of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA., Lott IT; Department of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA., Schupf N; Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Brickman AM; Gertrude. H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Jazyk: angličtina
Zdroj: Sleep advances : a journal of the Sleep Research Society [Sleep Adv] 2022 May 05; Vol. 3 (1), pp. zpac013. Date of Electronic Publication: 2022 May 05 (Print Publication: 2022).
DOI: 10.1093/sleepadvances/zpac013
Abstrakt: We determined the extent to which obstructive sleep apnea (OSA) is associated with increased cerebrovascular disease and amyloid burden, and the relation of the two processes across clinical Alzheimer's disease (AD) diagnostic groups in adults with Down syndrome (DS). Adults with DS from the Biomarkers of Alzheimer's Disease in Down Syndrome (ADDS) study were included given available research MRI ( n = 116; 50 ± 8 years; 42% women) and amyloid PET scans ( n = 71; 50 ± 7 years; 39% women) at the time of analysis. Participants were characterized as cognitively stable (CS; 64%), with mild cognitive impairment-DS (MCI-DS; 23%), with possible AD dementia (5%), or with definite AD dementia (8%). OSA was determined via medical records and interviews. Models tested the effect of OSA on MRI-derived cerebrovascular biomarkers and PET-derived amyloid burden, and the moderating effect of OSA and AD diagnosis on biomarkers. OSA was reported in 39% of participants, which did not differ by clinical AD diagnostic group. OSA was not associated with cerebrovascular biomarkers but was associated with greater cortical amyloid burden. White matter hyperintensity (WMH) volume (primarily in the parietal lobe), enlarged perivascular spaces, and cortical and striatal amyloid burden were greater across clinical AD diagnostic groups (CS (© The Author(s) 2022. Published by Oxford University Press on behalf of Sleep Research Society.)
Databáze: MEDLINE