A Highly Water- and Air-Stable Iron-Containing MRI Contrast Agent Sensor for H 2 O 2 .

Autor: Karbalaei S; Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA., Franke A; Department of Chemistry, Ludwig-Maximilians-Universität München, 81377, München, Germany., Jordan A; Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA., Rose C; Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA., Pokkuluri PR; Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA., Beyers RJ; Auburn University Magnetic Resonance Imaging Research Center, Auburn, AL 36849, USA., Zahl A; Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuremberg, 91058, Erlangen, Germany., Ivanović-Burmazović I; Department of Chemistry, Ludwig-Maximilians-Universität München, 81377, München, Germany., Goldsmith CR; Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Aug 16; Vol. 28 (46), pp. e202201179. Date of Electronic Publication: 2022 Jun 24.
DOI: 10.1002/chem.202201179
Abstrakt: A highly water- and air-stable Fe(II) complex with the quinol-containing macrocyclic ligand H 4 qp4 reacts with H 2 O 2 to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or two para-quinones. The reaction increases the T 1 -weighted relaxivity over four-fold, enabling the complex to detect H 2 O 2 using clinical MRI technology. The iron-containing sensor differs from its recently characterized manganese analog, which also detects H 2 O 2 , in that it is the oxidation of the metal center, rather than the ligand, that primarily enhances the relaxivity.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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