Non-Coding RNA in Penile Cancer.
| Autor: | Pinho JD; Zé Doca Center for Higher Studies, State University of Maranhão, Zé Doca, Brazil.; Laboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.; Oncology Research Center, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Silva GEB; Laboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil., Teixeira-Júnior AAL; Laboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.; Department of Genetics, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil., Rocha TMS; Laboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil., Batista LL; Oncology Research Center, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.; Coordination of Medicine, Federal University of Amapá, Macapá, Brazil., de Sousa AM; Oncology Research Center, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Calixto JRR; Department of Medicine, University Hospital of the Federal University of Maranhão, São Luís, Brazil., Burbano RR; Laboratory Biology Molecular, Ophir Loyola Hospital Ophir, Belém, Brazil., de Souza CRT; Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Khayat AS; Oncology Research Center, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in oncology [Front Oncol] 2022 May 13; Vol. 12, pp. 812008. Date of Electronic Publication: 2022 May 13 (Print Publication: 2022). |
| DOI: | 10.3389/fonc.2022.812008 |
| Abstrakt: | Penile cancer (PC) still presents a health threat for developing countries, in particular Brazil. Despite this, little progress has been made on the study of markers, including molecular ones, that can aid in the correct management of the patient, especially concerning lymphadenectomy. As in other neoplasms, non-coding RNAs (ncRNAs) have been investigated for penile cancer, with emphasis on microRNAs, piRNAs (PIWI-interacting small RNAs), and long non-coding RNAs (LncRNAs). In this context, this review aims to assemble the available knowledge on non-coding RNA linked in PC, contributing to our understanding of the penile carcinogenesis process and addressing their clinical relevance. ncRNAs are part of the novel generation of biomarkers, with high potential for diagnosis and prognosis, orientating the type of treatment. Furthermore, its versatility regarding the use of paraffin samples makes it possible to carry out retrospective studies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Pinho, Silva, Teixeira-Júnior, Rocha, Batista, de Sousa, Calixto, Burbano, Souza and Khayat.) |
| Databáze: | MEDLINE |
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