Evolution of genes involved in the unusual genitals of the bear macaque, Macaca arctoides .

Autor: Stevison LS; Department of Biological Sciences Auburn University Auburn Alabama USA., Bailey NP; Department of Biological Sciences Auburn University Auburn Alabama USA., Szpiech ZA; Department of Biological Sciences Auburn University Auburn Alabama USA.; Department of Biology Pennsylvania State University University Park Pennsylvania USA.; Institute for Computational and Data Sciences Pennsylvania State University University Park Pennsylvania USA., Novak TE; Department of Biological Sciences Auburn University Auburn Alabama USA., Melnick DJ; Department of Ecology, Evolution, and Environmental Biology Columbia University New York New York USA., Evans BJ; Biology Department McMaster University Hamilton Ontario Canada., Wall JD; Institute for Human Genetics University of California, San Francisco San Francisco California USA.
Jazyk: angličtina
Zdroj: Ecology and evolution [Ecol Evol] 2022 May 24; Vol. 12 (5), pp. e8897. Date of Electronic Publication: 2022 May 24 (Print Publication: 2022).
DOI: 10.1002/ece3.8897
Abstrakt: Genital divergence is thought to contribute to reproductive barriers by establishing a "lock-and-key" mechanism for reproductive compatibility. One such example, Macaca arctoides , the bear macaque, has compensatory changes in both male and female genital morphology as compared to close relatives. M . arctoides also has a complex evolutionary history, having extensive introgression between the fascicularis and sinica macaque species groups. Here, phylogenetic relationships were analyzed via whole-genome sequences from five species, including M . arctoides , and two species each from the putative parental species groups. This analysis revealed ~3x more genomic regions supported placement in the sinica species group as compared to the fascicularis species group. Additionally, introgression analysis of the M . arctoides genome revealed it is a mosaic of recent polymorphisms shared with both species groups. To examine the evolution of their unique genital morphology further, the prevalence of candidate genes involved in genital morphology was compared against genome-wide outliers in various population genetic metrics of diversity, divergence, introgression, and selection, while accounting for background variation in recombination rate. This analysis identified 67 outlier genes, including several genes that influence baculum morphology in mice, which were of interest since the bear macaque has the longest primate baculum. The mean of four of the seven population genetic metrics was statistically different in the candidate genes as compared to the rest of the genome, suggesting that genes involved in genital morphology have increased divergence and decreased diversity beyond expectations. These results highlight specific genes that may have played a role in shaping the unique genital morphology in the bear macaque.
(© 2022 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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