Association of Strongyloides stercoralis infection and type 2 diabetes mellitus in northeastern Thailand: Impact on diabetic complication-related renal biochemical parameters.

Autor: Yingklang M; Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.; Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Chaidee A; Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Dangtakot R; Department of Medical Technology, Faculty of Allied Health Science, Nakhon Ratchasima College, Nakhon Ratchasima, Thailand., Jantawong C; Department of Medical Technology, Faculty of Allied Health Science, Nakhon Ratchasima College, Nakhon Ratchasima, Thailand., Haonon O; Department of Medical Technology, Faculty of Allied Health Science, Nakhon Ratchasima College, Nakhon Ratchasima, Thailand., Sitthirach C; Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Hai NT; Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Parasitology, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam., Cha'on U; Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Anutrakulchai S; Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Kamsa-Ard S; Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand., Pinlaor S; Chronic Kidney Disease Prevention in The Northeastern Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 May 31; Vol. 17 (5), pp. e0269080. Date of Electronic Publication: 2022 May 31 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0269080
Abstrakt: Background: Several studies have demonstrated that helminth infections provide a degree of protection against Type 2 diabetes mellitus (T2DM). However, the relationship between Strongyloides stercoralis infection and T2DM has scarcely been investigated and the protective effect of infection against development of diabetic complications is unclear. In this study, we aimed to investigate the relationship between S. stercoralis infection and T2DM in a rural area of Khon Kaen Province, Thailand. The impact of S. stercoralis infection on diabetic complication-related kidney function biochemical parameters and body-mass index (BMI) was also assessed.
Methodology: Using a cross-sectional study design, S. stercoralis infection and T2DM assessments were conducted between October 2020 and May 2021. Associations between S. stercoralis infection, T2DM, and socioeconomic factors were analyzed using multivariable logistic regression analyses. Diabetic complication-related biochemical parameters relating largely to kidney function (estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), serum creatinine, uric acid, alanine transaminase (ALT), and low-density lipoprotein cholesterol (LDL-C)) and BMI of participants with and without T2DM were compared between groups with or without S. stercoralis infection.
Results: One hundred and seven out of 704 individuals (15.20%) were positive for S. stercoralis, and 283 people were diagnosed with T2DM. Of those with T2DM, 11.31% (32/283) were infected with S. stercoralis and of those without T2DM, 17.82% (75/421) were infected with S. stercoralis. Multivariate analysis revealed that T2DM was inversely correlated with S. stercoralis infection (Adjusted OR  =  0.49; 95% CI: 0.30, 0.78; p  = 0.003), while male, increasing age, lower education level, and alcohol intake were positively associated with infection. Those infected with S. stercoralis had lower eGFR levels and higher ALT and UACR levels than those in the uninfected group.
Conclusion: This finding indicates that S. stercoralis infection was inversely associated with T2DM in northeastern Thailand, but participants infected with S. stercoralis had lower eGFR levels and higher ALT and UACR levels. Infection with S. stercoralis might lead to worse complication-related renal biochemical parameters.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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