| Autor: |
Bendary MM; Department of Microbiology and Immunology, Faculty of Pharmacy, Port Said University, Port Said 42511, Egypt., Abdel-Hamid MI; Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt., Alshareef WA; Department of Microbiology and Immunology, Faculty of Pharmacy, October 6 University, 6 October 12566, Egypt., Alshareef HM; Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Tabuk, Saudi Arabia., Mosbah RA; Infection Control Unit, Zagazig University Hospital, Zagazig 44511, Egypt., Omar NN; Department of Biochemistry, Faculty of Pharmacy, Modern University for Technology and Information, Cairo 19448, Egypt., Al-Sanea MM; Pharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka 72341, Al-Jouf, Saudi Arabia., Alhomrani M; Department of Clinical Laboratories Sciences, The Faculty of Applied Medical Science, Taif University, Taif 26432, Makkah, Saudi Arabia.; Centre of Biomedical Science Research (CBSR), Deanship of Scientific Research, Taif University, Taif 26432, Makkah, Saudi Arabia., Alamri AS; Department of Clinical Laboratories Sciences, The Faculty of Applied Medical Science, Taif University, Taif 26432, Makkah, Saudi Arabia.; Centre of Biomedical Science Research (CBSR), Deanship of Scientific Research, Taif University, Taif 26432, Makkah, Saudi Arabia., Moustafa WH; Microbiology and immunology Department, Faculty of Pharmacy, Helwan University, Cairo 19448, Egypt. |
| Abstrakt: |
Widespread multidrug-resistant (MDR) and multi-virulent diarrheagenic E. coli create several crises among human and animal populations worldwide. For this reason, we looked forward to a breakthrough with this issue and tried to highlight these emerging threats. A total of 140 diarrheagenic E. coli isolates were recovered from animal and human sources. The O26 serotype, alongside the ampicillin/cefoxitin resistance phenotype, was predominant among both human and animal isolates. Of note, imipenem represented the most effective antibiotic against all the investigated isolates. Unfortunately, 90% and 57.9% of the tested isolates showed MDR and multi-virulent patterns, respectively. The animal isolates were more virulent and showed higher sensitivity to antimicrobial agents. Both animal and human isolates could not be arranged into related clusters. A strong negative correlation between the existence of virulence genes and antimicrobial resistance was clearly detected. A significant correlation between serotypes and antimicrobial resistance was not detected; meanwhile, a significant positive correlation between some serotypes and the presence of certain virulence genes was announced. Finally, our results confirmed the urgent need for restricted guidelines, in addition to new alternative therapies, due to the genetic diversity and wide spreading of MDR side by side with multi-virulent E. coli isolates. |
