Trichinella -induced immunomodulation: Another tale of helminth success.
| Autor: | Bruschi F; School of Medicine, Department of Translational Research, N.T.M.S., Università di Pisa, Pisa, Italy., Ashour DS; Department of Medical Parasitology, Faculty of Medicine, Tanta University, Tanta, Egypt., Othman AA; Department of Medical Parasitology, Faculty of Medicine, Tanta University, Tanta, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Food and waterborne parasitology [Food Waterborne Parasitol] 2022 May 16; Vol. 27, pp. e00164. Date of Electronic Publication: 2022 May 16 (Print Publication: 2022). |
| DOI: | 10.1016/j.fawpar.2022.e00164 |
| Abstrakt: | Trichinella spiralis is a unique parasite in that both the adults and larvae survive in two different intracellular niches in the same host. The immune response, albeit intense, is highly modulated to ensure the survival of both the host and the parasite. It is skewed to T helper 2 and regulatory arms. Diverse cells from both the innate and adaptive compartments of immunity, including dendritic cells, T regulatory cells, and alternatively activated macrophages are thought to mediate such immunomodulation. The parasite has also an outstanding ability to evade the immune system by several elaborate processes. The molecules derived from the parasites including Trichinella , particularly the components of the excretory-secretory products, are being continually identified and explored for the potential of ameliorating the immunopathology in animal models of diverse inflammatory and autoimmune human diseases. Herein we discuss the various aspects of Trichinella -induced immunomodulation with a special reference to the practical implications of the immune system manipulation in alleviating or possibly curing human diseases. Competing Interests: On behalf of other Authors Dalia Ashour and Ahmad Othman I declare that we have no conflict of interests. (© 2022 The Authors.) |
| Databáze: | MEDLINE |
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