| Autor: |
Kutlubaev MA; Bashkir state medical university, Ufa, Russia., Pervushina EV; Bashkir state medical university, Ufa, Russia., Areprintceva DK; Bashkir state medical university, Ufa, Russia., Mendelevich VD; Kazan state medical university, Kazan, Russia., Brylev LV; Buyanov Moscow city clinical hospital, Moscow, Russia. |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2022; Vol. 122 (5), pp. 36-42. |
| DOI: |
10.17116/jnevro202212205136 |
| Abstrakt: |
Neuropsychiatric presentations are observed in a substantial number of patients with amyotrophic lateral sclerosis (ALS). Severe behavioral disorders develop in ALS combined with frontotemporal dementia, which are considered to be a disease continuum. Psychiatric disorders in ALS with predominantly motor symptoms are less prominent and mostly presented with apathy. Psychiatric disorders in ALS by their origin could be psychogenic, reflecting the patients' reactions on severe disease, and organic, developing as a result of degeneration of central motor neurons and disconnection between fronto-subcortical and frontotemporal loops. An important role in the development of psychiatric disorders in ALS belongs to genetic factors, in particular to hexanucleotide expansion in the C9orf72 gene. During the first months after establishing the diagnosis of ALS, there is the high risk of developing depressive disorders, which in severe cases can lead to suicide. More research is needed in this area. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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