Oral candidiasis in patients with haematological diseases: Diagnosis through clinical and cytopathological examinations.

Autor: Pereira FGA; Postgraduate Program in Pathology, School of Medicine, Universidade Federal Fluminense (UFF), Niterói, Brazil., Milagres A; Department of Pathology, School of Medicine, Universidade Federal Fluminense (UFF), Niterói, Brazil., Werneck JT; Department of Specific Formation, School of Dentistry, Universidade Federal Fluminense, Rio de Janeiro, Brazil., Marques LC; Postgraduate Program in Pathology, School of Medicine, Universidade Federal Fluminense (UFF), Niterói, Brazil., Picciani BLS; Department of Specific Formation, School of Dentistry, Universidade Federal Fluminense, Rio de Janeiro, Brazil., Junior AS; Postgraduate Program in Pathology, School of Medicine, Universidade Federal Fluminense (UFF), Niterói, Brazil.
Jazyk: angličtina
Zdroj: Cytopathology : official journal of the British Society for Clinical Cytology [Cytopathology] 2022 Sep; Vol. 33 (5), pp. 611-617. Date of Electronic Publication: 2022 Jun 24.
DOI: 10.1111/cyt.13151
Abstrakt: Objective: This study is the first to analyse the prevalence of oral candidiasis in onco-haematological patients by physical and oral cytopathological examinations.
Methods: This is a cross-sectional and observational study with a retrospective sample composed of participants hospitalised in the haematology clinic, who were diagnosed with haematological diseases. All participants received an oral mucosal examination and scraping from oral mucosa.
Results: Of the 62 participants, 56.5% were male and 82.3% were white, with mean age of 57 years. Lymphoma was the most common haematological disease (24.2%). In total, 48.4% of the sample was diagnosed with oral candidiasis. Of the participants with oral candidiasis, 13 (21.0%) had a clinical diagnosis. Cytopathological analysis revealed 17 more (27.4%) cases without oral lesions indicative of candidiasis. Erythematous candidiasis (P = 0.02), pseudomembranous candidiasis (P < 0.001), clinical candidiasis (P < 0.001), fibrous hyperplasia (P = 0.032), and coated tongue (P = 0.012) showed a correlation with a candidiasis cytopathological diagnosis.
Conclusions: Oral candidiasis is common among patients with haematological disease, and the cytopathological examination proved to be a useful tool, confirming clinical diagnosis of candidiasis and identifying subclinical cases. These data are of great relevance considering the possible complications that these patients may develop, such as longer hospitalisations, worsening of the general condition or even death due to candidemia.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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