Ephaptic Coupling Is a Mechanism of Conduction Reserve During Reduced Gap Junction Coupling.
Autor: | Lin J; Department of Mathematics, California Polytechnic State University, San Luis Obispo, CA, United States., Abraham A; Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.; Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine, Roanoke, VA, United States., George SA; Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.; Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States., Greer-Short A; Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.; Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States., Blair GA; Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.; Translational Biology, Medicine and Health, Virginia Tech, Roanoke, VA, United States., Moreno A; Department of Biomedical Engineering, The George Washington University, Washington, DC, United States., Alber BR; Department of Biomedical Engineering, The George Washington University, Washington, DC, United States., Kay MW; Department of Biomedical Engineering, The George Washington University, Washington, DC, United States., Poelzing S; Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.; Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.; Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States.; Translational Biology, Medicine and Health, Virginia Tech, Roanoke, VA, United States. |
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Jazyk: | angličtina |
Zdroj: | Frontiers in physiology [Front Physiol] 2022 May 05; Vol. 13, pp. 848019. Date of Electronic Publication: 2022 May 05 (Print Publication: 2022). |
DOI: | 10.3389/fphys.2022.848019 |
Abstrakt: | Many cardiac pathologies are associated with reduced gap junction (GJ) coupling, an important modulator of cardiac conduction velocity (CV). However, the relationship between phenotype and functional expression of the connexin GJ family of proteins is controversial. For example, a 50% reduction of GJ coupling has been shown to have little impact on myocardial CV due to a concept known as conduction reserve. This can be explained by the ephaptic coupling (EpC) theory whereby conduction is maintained by a combination of low GJ coupling and increased electrical fields generated in the sodium channel rich clefts between neighboring myocytes. At the same time, low GJ coupling may also increase intracellular charge accumulation within myocytes, resulting in a faster transmembrane potential rate of change during depolarization ( dV/dt_max ) that maintains macroscopic conduction. To provide insight into the prevalence of these two phenomena during pathological conditions, we investigated the relationship between EpC and charge accumulation within the setting of GJ remodeling using multicellular simulations and companion perfused mouse heart experiments. Conduction along a fiber of myocardial cells was simulated for a range of GJ conditions. The model incorporated intercellular variations, including GJ coupling conductance and distribution, cell-to-cell separation in the intercalated disc (perinexal width-W Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Lin, Abraham, George, Greer-Short, Blair, Moreno, Alber, Kay and Poelzing.) |
Databáze: | MEDLINE |
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