The impact of short-term confinement on human innate immunity.

Autor: Ponomarev SA; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation. dr.grey@bk.ru., Sadova AA; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation.; Pirigov Russian National Research Medical University (Pirogov Medical University), Moscow, 117997, Russian Federation., Rykova MP; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation., Orlova KD; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation., Vlasova DD; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation., Shulgina SM; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation., Antropova EN; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation., Kutko OV; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation., Germanov NS; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation.; Pirigov Russian National Research Medical University (Pirogov Medical University), Moscow, 117997, Russian Federation., Galina VS; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation.; Pirigov Russian National Research Medical University (Pirogov Medical University), Moscow, 117997, Russian Federation., Shmarov VA; Laboratory of Immune System Physiology, SSC RF-IBMP RAS, Moscow, 123007, Russian Federation.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 May 19; Vol. 12 (1), pp. 8372. Date of Electronic Publication: 2022 May 19.
DOI: 10.1038/s41598-022-12380-5
Abstrakt: During space missions cosmonauts are exposed to a myriad of distinct stressors such as radiation, overloads, weightlessness, radiation, isolation in artificial environmental conditions, which causes changes in immune system. During space flights it is very difficult to determine the particular factor associated with the observed immunological responses. This makes ground-based experiments examining the effect of each space flight associated factor along of particular value. Determining mechanisms causing alterations in cosmonauts' immunity can lead to potential targets for different countermeasures. In the current article we present the study of the early period of adaptation of human innate immunity of 6 healthy test-subjects, 4 males and 2 females aged 25 through 40, to isolation factors (hypodynamia, psychological stress, artificial environment). We measured multiple parameters characterizing innate immunity status in blood samples at chosen time points before, during and after the mission. In the experiment, highly enhanced cytokine responses were observed upon ex vivo antigen stimulations in comparison to baseline values. For cellular parameters we found multidirectional dynamics with a persistent prevalence of increasing TLRs + monocytes as well as TLRs expression. Our study provides evidence that even a short-term confinement leads to immune changes in healthy humans that may trigger aberrant immune response.
(© 2022. The Author(s).)
Databáze: MEDLINE
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