Reflected stemness as a potential driver of the tumour microenvironment.

Autor: Rodrigues FS; Tumour-Host Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Ciccarelli FD; Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK., Malanchi I; Tumour-Host Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK. Electronic address: Ilaria.malanchi@crick.ac.uk.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2022 Dec; Vol. 32 (12), pp. 979-987. Date of Electronic Publication: 2022 May 16.
DOI: 10.1016/j.tcb.2022.04.007
Abstrakt: A fundamental requirement for cancer initiation is the activation of developmental programmes by mutant cells. Oncogenic signals often confer an undifferentiated, stem cell-like phenotype that supports the long-term proliferative potential of cancer cells. Although cancer is a genetically driven disease, mutations in cancer-driver genes alone are insufficient for tumour formation, and the proliferation of cells harbouring oncogenic mutations depends on their microenvironment. In this Opinion article we discuss how the reprogrammed status of cancer cells not only represents the essence of their tumorigenicity but triggers 'reflected stemness' in their surrounding normal counterparts. We propose that this reciprocal interaction underpins the establishment of the tumour microenvironment (TME).
Competing Interests: Declaration of interests The authors declare no conflicts of interest.
(Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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