Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study.

Autor: Ewald VAM; Department of Psychiatry, The University of Iowa, 195-207 Newton Road, Iowa City, IA, 52246, USA., Purnell JR; Department of Psychiatry, The University of Iowa, 195-207 Newton Road, Iowa City, IA, 52246, USA., Bruss JE; Department of Neurology, The University of Iowa, Iowa City, IA, USA., Barsotti EJ; Department of Epidemiology, The University of Iowa, Iowa City, IA, USA., Aldine AS; Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Mahachi KG; Department of Epidemiology, The University of Iowa, Iowa City, IA, USA., Wemmie JA; Department of Psychiatry, The University of Iowa, 195-207 Newton Road, Iowa City, IA, 52246, USA., Magnotta VA; Department of Psychiatry, The University of Iowa, 195-207 Newton Road, Iowa City, IA, 52246, USA.; Department of Radiology, The University of Iowa, Iowa City, IA, USA.; Department of Biomedical Engineering, The University of Iowa, Iowa City, IA, USA., Boes AD; Department of Psychiatry, The University of Iowa, 195-207 Newton Road, Iowa City, IA, 52246, USA.; Department of Pediatrics, The University of Iowa, Iowa City, IA, USA., Parker KL; Department of Psychiatry, The University of Iowa, 195-207 Newton Road, Iowa City, IA, 52246, USA. krystal-parker@uiowa.edu., Fiedorowicz JG; Brain and Mind Institute, University of Ottawa, The Ottawa Hospital and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2023 Jun; Vol. 22 (3), pp. 370-378. Date of Electronic Publication: 2022 May 14.
DOI: 10.1007/s12311-022-01408-1
Abstrakt: Posterior fossa arachnoid cysts (PFACs) are rare congenital abnormalities observed in 0.3 to 1.7% of the population and are traditionally thought to be benign. While conducting a neuroimaging study investigating cerebellar structure in bipolar disorder, we observed a higher incidence of PFACs in bipolar patients (5 of 75; 6.6%) compared to the neuronormative control group (1 of 54; 1.8%). In this report, we detail the cases of the five patients with bipolar disorder who presented with PFACs. Additionally, we compare neuropsychiatric measures and cerebellar volumes of these patients to neuronormative controls and bipolar controls (those with bipolar disorder without neuroanatomical abnormalities). Our findings suggest that patients with bipolar disorder who also present with PFACs may have a milder symptom constellation relative to patients with bipolar disorder and no neuroanatomical abnormalities. Furthermore, our observations align with prior literature suggesting an association between PFACs and psychiatric symptoms that warrants further study. While acknowledging sample size limitations, our primary aim in the present work is to highlight a connection between PFACs and BD-associated symptoms and encourage further study of cerebellar abnormalities in psychiatry.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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