Distinct neural codes in primate hippocampus and lateral prefrontal cortex during associative learning in virtual environments.

Autor:	Corrigan BW; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada; Robarts Research Institute, University of Western Ontario, London, ON, Canada; Brain and Mind Institute, University of Western Ontario, London, ON, Canada., Gulli RA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY, USA., Doucet G; The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada., Roussy M; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada; Robarts Research Institute, University of Western Ontario, London, ON, Canada; Brain and Mind Institute, University of Western Ontario, London, ON, Canada., Luna R; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada; Robarts Research Institute, University of Western Ontario, London, ON, Canada., Pradeepan KS; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada; Robarts Research Institute, University of Western Ontario, London, ON, Canada; Brain and Mind Institute, University of Western Ontario, London, ON, Canada., Sachs AJ; The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada., Martinez-Trujillo JC; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada; Robarts Research Institute, University of Western Ontario, London, ON, Canada; Brain and Mind Institute, University of Western Ontario, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada. Electronic address: julio.martinez@robarts.ca.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2022 Jul 06; Vol. 110 (13), pp. 2155-2169.e4. Date of Electronic Publication: 2022 May 12.
DOI:	10.1016/j.neuron.2022.04.016
Abstrakt:	The hippocampus (HPC) and the lateral prefrontal cortex (LPFC) are two cortical areas of the primate brain deemed essential to cognition. Here, we hypothesized that the codes mediating neuronal communication in the HPC and LPFC microcircuits have distinctively evolved to serve plasticity and memory function at different spatiotemporal scales. We used a virtual reality task in which animals selected one of the two targets in the arms of the maze, according to a learned context-color rule. Our results show that during associative learning, HPC principal cells concentrate spikes in bursts, enabling temporal summation and fast synaptic plasticity in small populations of neurons and ultimately facilitating rapid encoding of associative memories. On the other hand, layer II/III LPFC pyramidal cells fire spikes more sparsely distributed over time. The latter would facilitate broadcasting of signals loaded in short-term memory across neuronal populations without necessarily triggering fast synaptic plasticity. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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