Anticancer and antimicrobial properties of novel η 6 - p -cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization.

Autor:	Namiecińska E; Department of Cosmetic Raw Materials Chemistry, Medical University of Lodz Muszynskiego 1 90-151 Lodz Poland elzbieta.budzisz@umed.lodz.pl., Sadowska B; Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz Banacha 12/16 90-237 Lodz Poland., Więckowska-Szakiel M; Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz Banacha 12/16 90-237 Lodz Poland., Dołęga A; Department of Inorganic Chemistry, Faculty of Chemistry, Gdansk University of Technology Narutowicza 11/12 80-233 Gdansk Poland., Pasternak B; Department of Organic Chemistry, Faculty of Chemistry, University of Lodz Tamka 12 91-403 Lodz Poland., Grazul M; Department of Pharmaceutical Microbiology and Microbiological Diagnostics, Faculty of Pharmacy, Medical University of Lodz Pomorska 137 Street 90-235 Lodz Poland., Budzisz E; Department of Cosmetic Raw Materials Chemistry, Medical University of Lodz Muszynskiego 1 90-151 Lodz Poland elzbieta.budzisz@umed.lodz.pl.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2019 Nov 27; Vol. 9 (66), pp. 38629-38645. Date of Electronic Publication: 2019 Nov 27 (Print Publication: 2019).
DOI:	10.1039/c9ra08736b
Abstrakt:	Ruthenium(ii) complexes are lately of great scientific interest due to their chemotherapeutic potential as anticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamide derivatives and their four arene-ruthenium complexes. The title compounds were characterized with the application of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for new complexes DFT calculations were done. Their antimicrobial activity (MIC, MBC/MFC) was examined in vitro against Staphylococcus aureus , Staphylococcus epidermidis , Enterococcus faecalis , Pseudomonas aeruginosa , Proteus vulgaris and Candida albicans . Their cytotoxic effects, using the MTT assay, against three cancer cell lines: HL-60, NALM-6, WM-115 and normal human foreskin fibroblasts (HFF-1) were also investigated. The influence of the new arene-ruthenium(ii) complexes on the DNA structure was also tested. From our results, compound 2d showed higher cytotoxicity against melanoma cell line WM-115 than cisplatin. Strong biostatic and biocidal activity of the tested complexes against Gram-positive bacteria, including S. aureus , S. epidermidis and E. faecalis was demonstrated. The new arene-ruthenium(ii) compounds could not only inhibit proliferation of cancer cells, but also protect patients against malignant wound infections. Competing Interests: The authors declare no conflict of interests. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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