A nano-magnetic electrochemical sensor for the determination of mood disorder related substances.

Autor: Cincotto FH; Chemistry Department, Federal University of São Carlos 13565-905 São Carlos SP Brazil fernandocincotto@gmail.com fcmoraes@ufscar.br., Carvalho DAS; Chemistry Department, Federal University of São Carlos 13565-905 São Carlos SP Brazil fernandocincotto@gmail.com fcmoraes@ufscar.br., Canevari TC; Engineering School, Mackenzie Presbyterian University 01302-907 São Paulo SP Brazil., Toma HE; Institute of Chemistry, University of São Paulo 05508-000 São Paulo SP Brazil., Fatibello-Filho O; Chemistry Department, Federal University of São Carlos 13565-905 São Carlos SP Brazil fernandocincotto@gmail.com fcmoraes@ufscar.br., Moraes FC; Chemistry Department, Federal University of São Carlos 13565-905 São Carlos SP Brazil fernandocincotto@gmail.com fcmoraes@ufscar.br.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2018 Apr 16; Vol. 8 (25), pp. 14040-14047. Date of Electronic Publication: 2018 Apr 16 (Print Publication: 2018).
DOI: 10.1039/c8ra01857j
Abstrakt: The simultaneous electrochemical detection of mood disorder related substances, such as amitriptyline, melatonin and tryptophan, was successfully achieved by using a novel nano-magnetic electrochemical sensor design, encompassing Fe 3 O 4 nanoparticles decorated with carbon quantum dots (MagNPs/Cdots). The magnetic composite was characterized using HR-TEM microscopy, XRD and Raman spectroscopy, and was applied onto a glassy carbon electrode using a miniature neodymium magnet. The determination of amitriptyline, melatonin and tryptophan was performed by monitoring oxidation promoted by MagNPs/Cdots in BR-buffer at pH 3.0, which proceeded according to well-defined differential pulse voltammetry peaks, with detection limits of 5.9, 4.4 and 4.2 nmol L -1 , respectively. No significant interference was seen from biological interferents such as uric acid, ascorbic acid, dopamine, estriol and 17β-estradiol. The magnetic hybrid material was highly stable in solution, opening exciting opportunities for the development of low cost and practical electrochemical sensors for the determination of mood disorder related substances in real clinical samples.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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