Sex steroid modulation of macrophages within the prostate tumor microenvironment.

Autor:	Berrehail Z; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada., Boibessot C; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada., Gris T; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada., Joncas FH; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada., Gaignier F; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada., Guillemette C; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada.; Faculty of Pharmacy, Université Laval, CHU de Québec Research Center Quebec City, Quebec, Canada., Lacombe L; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada.; Department of Surgery, Université Laval Quebec City, Quebec, Canada., Fradet Y; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada.; Department of Surgery, Université Laval Quebec City, Quebec, Canada., Toren P; CHU de Québec-Université Laval Research Center Quebec City, Quebec, Canada.; Cancer Research Center, Université Laval Quebec City, Quebec, Canada.; Department of Surgery, Université Laval Quebec City, Quebec, Canada.
Jazyk:	angličtina
Zdroj:	American journal of clinical and experimental urology [Am J Clin Exp Urol] 2022 Apr 15; Vol. 10 (2), pp. 98-110. Date of Electronic Publication: 2022 Apr 15 (Print Publication: 2022).
Abstrakt:	Background: The role of androgens and other sex steroids is known to influence the prognosis and progression of prostate cancer through different disease states. While androgens are generally regarded as immunosuppressive and estrogens as inflammatory, the specific influence of sex steroids on the immune microenvironment of prostate tumors remains incompletely understood. Material and Methods: In this study, we evaluate the link between sex steroids and prostate cancer immune cells, particularly macrophages. Using in vitro and in vivo models, as well as ex vivo culture of patient prostate tissue, we evaluated the influence of androgen, estrogen, and progesterone on immune cells of the prostate microenvironment. Results: In vitro , we observed sex steroids induced indirect changes on prostate cancer cell proliferation via THP-1 derived macrophages, but no clear changes were induced using human monocyte derived macrophages. Comparing immunohistochemistry for immunosuppressive macrophage marker CD163 with concomitant circulating sex steroids from the same patients, we observed a correlation with higher dehydroepiandrosterone (DHEA)-sulfate and estrone-sulfate levels associated with higher prostate CD163 expression. Similar relationships between DHEA and CD163 levels were observed in ex vivo cultured prostate biopsies. Finally, in a murine prostate cancer model of long-term sex steroids we observed significant differences in tumor growth in mice implanted with estrogen and DHEA diffusion tubes. Conclusions: Our results highlight the complex influence of sex steroids on the immune cell composition of prostate tumors. Understanding this biology may help to further personalized therapy and improve patient outcomes. Competing Interests: None. (AJCEU Copyright © 2022.)
Databáze:	MEDLINE
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