Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP 3 R-dependent resistance to ER stress-induced cell death.

Autor: Lemos FO; KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000, Leuven, Belgium., de Ridder I; KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000, Leuven, Belgium., Bultynck G; KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000, Leuven, Belgium. Electronic address: geert.bultynck@kuleuven.be., Parys JB; KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000, Leuven, Belgium. Electronic address: jan.parys@kuleuven.be.
Jazyk: angličtina
Zdroj: Cell calcium [Cell Calcium] 2022 Jun; Vol. 104, pp. 102593. Date of Electronic Publication: 2022 Apr 30.
DOI: 10.1016/j.ceca.2022.102593
Abstrakt: Anti-apoptotic BCL-2 targets and inhibits IP 3 receptors (IP 3 Rs), thereby preventing apoptosis by limiting ER-mitochondrial Ca 2+ flux. Recently, Dulloo et al. (2022), Nat. Comm. 13:1257[6] revealed a novel role for rhomboid pseudoproteases in ER stress-induced apoptosis by stripping BCL-2 from IP 3 Rs, thereby enabling pro-apoptotic Ca 2+ signaling.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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