Development of neurochemical labeling in the intermediolateral nucleus of cats' spinal cord.

Autor: Veshchitskii AA; Laboratory of Neuromorphology, Pavlov Institute of Physiology RAS, Saint-Petersburg, Russia., Kirik OV; Laboratory of Functional Morphology of Central and Peripheral Nervous System, Institute of Experimental Medicine RAS, Saint-Petersburg, Russia., Korzhevskii DE; Laboratory of Functional Morphology of Central and Peripheral Nervous System, Institute of Experimental Medicine RAS, Saint-Petersburg, Russia., Merkulyeva N; Laboratory of Neuromorphology, Pavlov Institute of Physiology RAS, Saint-Petersburg, Russia.
Jazyk: angličtina
Zdroj: Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2023 Sep; Vol. 306 (9), pp. 2400-2410. Date of Electronic Publication: 2022 May 02.
DOI: 10.1002/ar.24943
Abstrakt: NeuN is a neuron-specific nuclear protein expressed in most mature neuronal cell types, with some exceptions. These exceptions are known mainly for the brain but not for the spinal cord or the spinal visceral networks for which only scarce information is available. One of the most defined visceral structures in the spinal cord is the sympathetic intermediolateral nucleus located within the thoracolumbar segments. We investigated the NeuN staining in the intermediolateral nucleus and compared it with the staining for two neurochemical markers of visceral neurons: nitric oxide synthase and calcium-binding protein calretinin in adult cats and in kittens aged 0, 14, and 35 days. A clear NeuN-immunonegativity was obtained for intermediolateral neurons labeled for nitric oxide synthase for both adult cats and kittens. In contrast, a matched immunopositivity for the NeuN and calretinin was obtained, showing an age-dependent degree of this colocalization, which was high in newborn kittens, decreased on postnatal 14 and 35 days and persisted at a moderate level up to adulthood. Perhaps our data displayed a heterogeneity of the intermediolateral neurons.
(© 2022 American Association for Anatomy.)
Databáze: MEDLINE
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