Lateral sinus thrombosis in a young patient with sudden neurosensorial hearing loss and genetic thrombophilia: A case report.

Autor: Cuzmici-Barabaș Z; Department of Molecular Sciences, University of Medicine and Pharmacy, 4000012 Cluj-Napoca, Romania.; Department of Oncogenetics, 'I. Chiricuță' Institute of Oncology, 4000015 Cluj-Napoca, Romania., Cătană A; Department of Molecular Sciences, University of Medicine and Pharmacy, 4000012 Cluj-Napoca, Romania.; Department of Oncogenetics, 'I. Chiricuță' Institute of Oncology, 4000015 Cluj-Napoca, Romania., Militaru MS; Department of Molecular Sciences, University of Medicine and Pharmacy, 4000012 Cluj-Napoca, Romania.; Department of Oncogenetics, 'I. Chiricuță' Institute of Oncology, 4000015 Cluj-Napoca, Romania., Garbea O; Department of Molecular Sciences, University of Medicine and Pharmacy, 4000012 Cluj-Napoca, Romania., Cătană IV; Department of Otorhynolaringology, 'Venart' Clinic, 400486 Cluj Napoca, Romania., Pop IV; Department of Molecular Sciences, University of Medicine and Pharmacy, 4000012 Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2022 Jun; Vol. 23 (6), pp. 387. Date of Electronic Publication: 2022 Apr 12.
DOI: 10.3892/etm.2022.11314
Abstrakt: Sensorineural hearing loss (SSHL) with a sudden onset is frequently encountered as a medical emergency in the ear, nose and throat (ENT) practice. The exact pathophysiology of the disease remains unknown, with the most likely etiologies being viral infection, inflammation, drug toxicity, trauma, or autoimmune response. Even though thrombophilia and cerebrovascular complications may lead, among others, to sudden neurosensorial hearing loss, its diagnosis is most often made following the onset of thrombotic complications. A case of a young female patient with unknown congenital hypercoagulation status complicated with lateral sinus thrombosis and unilateral drug-induced reversible hearing loss is presented. Molecular testing confirmed the diagnosis of genetic thrombophilia, due to the homozygous V Leiden, homozygous MTHFR A1298C, and heterozygous MTHFR C677T mutations. Although hereditary thrombophilia is a well-known topic in medical practice, current guidelines require continuous improvement, especially among patients treated in departments where this pathology is more difficult to recognize and manage.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © Cuzmici-Barabaș et al.)
Databáze: MEDLINE
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