Upregulated genes in articular cartilage may help to counteract femoral head separation in broilers with 21 days of age.

Autor: Santos CE; Programa de Pós-Graduação em Ciências Veterinárias, Universidade Estadual do Centro-Oeste, 85040-080 Guarapuava, Paraná, Brazil., Peixoto JO; Programa de Pós-Graduação em Ciências Veterinárias, Universidade Estadual do Centro-Oeste, 85040-080 Guarapuava, Paraná, Brazil; Embrapa Suínos e Aves, 89715-899 Concórdia, Santa Catarina, Brazil. Electronic address: jane.peixoto@embrapa.br., Fernandes LT; Embrapa Suínos e Aves, 89715-899 Concórdia, Santa Catarina, Brazil., Marcelino DEP; Faculdade de Concórdia FACC, 89701-130 Concórdia, Santa Catarina, Brazil., Kawski VL; Embrapa Suínos e Aves, 89715-899 Concórdia, Santa Catarina, Brazil. Electronic address: vicky.kawski@embrapa.br., Neis FT; Instituto Federal Catarinense, 89703-720 Concórdia, Santa Catarina, Brazil., Ledur MC; Embrapa Suínos e Aves, 89715-899 Concórdia, Santa Catarina, Brazil; Programa de Pós-Graduação em Zootecnia, Centro de Educação Superior do Oeste (CEO), Universidade do Estado de Santa Catarina (UDESC), 89815-630 Chapecó, Santa Catarina, Brazil. Electronic address: monica.ledur@embrapa.br., Ibelli AMG; Programa de Pós-Graduação em Ciências Veterinárias, Universidade Estadual do Centro-Oeste, 85040-080 Guarapuava, Paraná, Brazil; Embrapa Suínos e Aves, 89715-899 Concórdia, Santa Catarina, Brazil. Electronic address: adriana.ibelli@embrapa.br.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2022 Oct; Vol. 147, pp. 92-95. Date of Electronic Publication: 2022 Apr 25.
DOI: 10.1016/j.rvsc.2022.04.006
Abstrakt: Femoral head necrosis (FHN) is one of the most common conditions in fast growing broilers, being characterized by separation of articular cartilage from epiphysis and classified as femoral head separation (FHS) or FHS with laceration (FHSL) depending on severity. Although molecular mechanisms involved with this disorder have been observed, its etiology is still unclear. Therefore, the expression of 15 candidate genes, chosen based on previous transcriptomic studies, was evaluated in the articular cartilage (AC) of normal and FHS-affected broilers at 21 days of age. Samples were collected based on the absence or presence of FHS for physical-chemical and qPCR analysis. The AvBD2, RHAG, COL28A1, ADA and ANGPTL7 were upregulated in FHS-affected broilers compared to the healthy group. These genes are involved in immune response, defense against pathogens, inflammation, cellular migration and adhesion, indicating different molecular mechanisms to control FHS progression at early age. Our results can contribute to improve the knowledge on FHN etiology in chickens and other species, such as horse and pigs that are severely affected by bone disorders.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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