Blastic Indeterminate Dendritic Cell Tumor Associated With Chronic Myelomonocytic Leukemia.
| Autor: | Ellis A; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Elbaz Younes I, Shao H, Zhang X |
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| Jazyk: | angličtina |
| Zdroj: | The American Journal of dermatopathology [Am J Dermatopathol] 2022 Sep 01; Vol. 44 (9), pp. 691-695. Date of Electronic Publication: 2022 Apr 11. |
| DOI: | 10.1097/DAD.0000000000002202 |
| Abstrakt: | Abstract: Indeterminate dendritic cell tumor (IDCT) is an exceedingly rare neoplasm that can be associated with hematopoietic malignancies. We report a case of multifocal cutaneous blastic indeterminate dendritic cell tumor (BIDCT) in a 75-year-old man with chronic myelomonocytic leukemia showing blastic histiocytoid morphology, positivity for CD1a and S100, and no expression of langerin. We present a literature review on the 11 reported cases of IDCTs/BIDCTs associated with chronic myelomonocytic leukemia (CMML), including this case. The clinicopathological characteristics have been summarized. The IDCT and CMML cells are clonally related in 4 tested cases. Patients with IDCT/BIDCT associated with CMML seem to have worse clinical outcomes compared with patients with IDCT not associated with CMML. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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