Pilot trial using mass field-releases of sterile males produced with the incompatible and sterile insect techniques as part of integrated Aedes aegypti control in Mexico.

Autor: Martín-Park A; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Che-Mendoza A; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Contreras-Perera Y; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Pérez-Carrillo S; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Puerta-Guardo H; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Villegas-Chim J; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Guillermo-May G; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Medina-Barreiro A; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Delfín-González H; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México., Méndez-Vales R; Servicios de Salud de Yucatán, Mérida, México., Vázquez-Narvaez S; Servicios de Salud de Yucatán, Mérida, México., Palacio-Vargas J; Servicios de Salud de Yucatán, Mérida, México., Correa-Morales F; Centro Nacional de Programas Preventivos y Control de Enfermedades (CENAPRECE), Secretaría de Salud, Ciudad de México, México., Ayora-Talavera G; Centro de Investigaciones Regionales 'Dr. Hideyo Noguchi', Universidad Autónoma de Yucatán, Mérida, México., Pavía-Ruz N; Centro de Investigaciones Regionales 'Dr. Hideyo Noguchi', Universidad Autónoma de Yucatán, Mérida, México., Liang X; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America., Fu P; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America.; School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China., Zhang D; Sun Yat-sen University-Michigan State University Joint Center of Vector Control for Tropical Diseases, Guangzhou, China., Wang X; Guangzhou Wolbaki Biotech Co. Ltd., Guangzhou, Guangdong, China., Toledo-Romaní ME; Departamento de Epidemiología, Instituto de Medicina Tropical 'Pedro Kourí' (IPK), La Habana, Cuba., Xi Z; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America.; Sun Yat-sen University-Michigan State University Joint Center of Vector Control for Tropical Diseases, Guangzhou, China., Vázquez-Prokopec G; Department of Environmental Sciences, Emory University, Atlanta, Georgia, United States of America., Manrique-Saide P; Laboratorio para el Control Biológico de Aedes aegypti (LCB-UADY), Unidad Colaborativa para Bioensayos Entomológicos, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, México.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Apr 26; Vol. 16 (4), pp. e0010324. Date of Electronic Publication: 2022 Apr 26 (Print Publication: 2022).
DOI: 10.1371/journal.pntd.0010324
Abstrakt: Background: The combination of Wolbachia-based incompatible insect technique (IIT) and radiation-based sterile insect technique (SIT) can be used for population suppression of Aedes aegypti. Our main objective was to evaluate whether open-field mass-releases of wAlbB-infected Ae. aegypti males, as part of an Integrated Vector Management (IVM) plan led by the Mexican Ministry of Health, could suppress natural populations of Ae. aegypti in urbanized settings in south Mexico.
Methodology/principal Findings: We implemented a controlled before-and-after quasi-experimental study in two suburban localities of Yucatan (Mexico): San Pedro Chimay (SPC), which received IIT-SIT, and San Antonio Tahdzibichén used as control. Release of wAlbB Ae. aegypti males at SPC extended for 6 months (July-December 2019), covering the period of higher Ae. aegypti abundance. Entomological indicators included egg hatching rates and outdoor/indoor adult females collected at the release and control sites. Approximately 1,270,000 lab-produced wAlbB-infected Ae. aegypti males were released in the 50-ha treatment area (2,000 wAlbB Ae. aegypti males per hectare twice a week in two different release days, totaling 200,000 male mosquitoes per week). The efficacy of IIT-SIT in suppressing indoor female Ae. aegypti density (quantified from a generalized linear mixed model showing a statistically significant reduction in treatment versus control areas) was 90.9% a month after initiation of the suppression phase, 47.7% two months after (when number of released males was reduced in 50% to match local abundance), 61.4% four months after (when initial number of released males was re-established), 88.4% five months after and 89.4% at six months after the initiation of the suppression phase. A proportional, but lower, reduction in outdoor female Ae. aegypti was also quantified (range, 50.0-75.2% suppression).
Conclusions/significance: Our study, the first open-field pilot implementation of Wolbachia IIT-SIT in Mexico and Latin-America, confirms that inundative male releases can significantly reduce natural populations of Ae. aegypti. More importantly, we present successful pilot results of the integration of Wolbachia IIT-SIT within a IVM plan implemented by Ministry of Health personnel.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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