Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer.

Autor:	Calmels L; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Sibolt P; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Åström LM; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.; Department of Health Technology, Technical University of Denmark, Roskilde, Denmark., Serup-Hansen E; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Lindberg H; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Fromm AL; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Persson G; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.; Department of Clinical Oncology, Copenhagen University, Copenhagen, Denmark., Sjöström D; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Geertsen P; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Behrens CP; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.; Department of Health Technology, Technical University of Denmark, Roskilde, Denmark.
Jazyk:	angličtina
Zdroj:	Technical innovations & patient support in radiation oncology [Tech Innov Patient Support Radiat Oncol] 2022 Apr 12; Vol. 22, pp. 30-36. Date of Electronic Publication: 2022 Apr 12 (Print Publication: 2022).
DOI:	10.1016/j.tipsro.2022.04.001
Abstrakt:	Background and Purpose: The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning system (aTPS) for both intensity-modulated radiotherapy (IMRT) and volumetric modulated arc radiotherapy (VMAT) plan creation. The purpose of this study is to evaluate the quality of aTPS plans in the pelvic region. Material and Methods: Sixty patients with anal (n = 20), rectal (n = 20) or prostate (n = 20) cancer were retrospectively re-planned with the aTPS. Three IMRT (7-, 9- and 12-field) and two VMAT (2 and 3 arc) automatically generated plans (APs) were created per patient. The duration of the automated plan generation was registered. The best IMRT-AP and VMAT-AP for each patient were selected based on target coverage and dose to organs at risk (OARs). The AP quality was analyzed and compared to corresponding clinically accepted and manually generated VMAT plans (MPs) using several clinically relevant dose metrics. Calculation-based pre-treatment plan quality assurance (QA) was performed for all plans. Results: The median total duration to generate the five APs with the aTPS was 55 min, 39 min and 35 min for anal, prostate and rectal plans, respectively. The target coverage and the OAR sparing were equivalent for IMRT-APs and VMAT-MPs, while VMAT-Aps.demonstrated lower target dose homogeneity and higher dose to some OARs. Both conformity and homogeneity index were equivalent (rectal) or better (anal and prostate) for IMRT-APs compared to VMAT-MPs. All plans passed the patient-specific QA tolerance limit. Conclusions: The aTPS generates plans comparable to MPs within a short time-frame which is highly relevant for oART treatments. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.)
Databáze:	MEDLINE
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