Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma.

Autor: Kulikov OA; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia., Zharkov MN; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia., Ageev VP; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia., Yakobson DE; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia., Shlyapkina VI; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia., Zaborovskiy AV; Department of Pharmacology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Delegatskaya Str. 20, 127473 Moscow, Russia., Inchina VI; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia., Balykova LA; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia., Tishin AM; Faculty of Physics, M.V. Lomonosov Moscow State University, Leninskie Gory 1-2, 119991 Moscow, Russia.; Pharmag LLC (AMT&C Group), Promyshlennaya Str. 4, 142190 Troitsk, Russia., Sukhorukov GB; School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK.; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, Bld. 1, 143025 Moscow, Russia., Pyataev NA; Institute of Medicine, National Research Ogarev Mordovia State University, Bolshevistskaya Str. 68, 430005 Saransk, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2022 Apr 11; Vol. 23 (8). Date of Electronic Publication: 2022 Apr 11.
DOI: 10.3390/ijms23084234
Abstrakt: In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was examined in vivo and found to be negligible. Histological examination showed a low local irritant effect and no effect on the morphology of the internal organs. The efficiency of magnetic hyperthermia for the treatment of transplanted Walker 256 carcinoma was evaluated. The tumour was infiltrated with the synthesised particles and then treated with an alternating magnetic field. The survival rate was 85% in the studied therapy group of seven animals, while in the control group (without treatment), all animals died. The physicochemical and pharmaceutical properties of the synthesised fluid and the therapeutic results, as seen in the in vivo experiments, provide insights into therapeutic hyperthermia using injected magnetite nanoparticles.
Databáze: MEDLINE
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