Prevalence of transfusion-transmitted infections in multiple blood transfusion-dependent thalassemic patients in Asia: A systemic review.

Autor:	Riaz M; Department of Allied Health Sciences, 66971University of Sargodha, Sargodha, Pakistan., Abbas M; Department of Biochemistry, 66920University of Veterinary and Animal Sciences Lahore (Jhang Campus), Jhang, Pakistan., Rasool G; Department of Allied Health Sciences, 66971University of Sargodha, Sargodha, Pakistan., Baig IS; Department of Biological Sciences, 66920University of Veterinary and Animal Sciences Lahore (Jhang Campus), Jhang, Pakistan., Mahmood Z; Department of Biochemistry, 72594Government College University Faisalabad, Faisalabad, Pakistan., Munir N; Department of Medical Laboratory Sciences, School of Health Sciences, University of Management and Technology, Lahore, Pakistan., Mahmood Tahir I; College of Allied Health Professionals, 72594Government College University Faisalabad, Faisalabad, Pakistan., Ali Shah SM; Department of Eastern Medicine, 72594Government College University Faisalabad, Faisalabad, Pakistan., Akram M; Department of Eastern Medicine, 72594Government College University Faisalabad, Faisalabad, Pakistan.
Jazyk:	angličtina
Zdroj:	International journal of immunopathology and pharmacology [Int J Immunopathol Pharmacol] 2022 Jan-Dec; Vol. 36, pp. 3946320221096909.
DOI:	10.1177/03946320221096909
Abstrakt:	Background: Thalassemia is a hereditary hemolytic anemia marked by a defect in synthesizing one or more globin chains in hemoglobin. In Pakistan, approximately 10,000 patients with thalassemia are primarily dependent on blood transfusions. The β-thalassemia patients require blood transfusions and iron chelation therapy. Patients who need blood transfusions are at an increased risk of contracting transfusion-transmitted infections (TTIs) such as hepatitis B and C viruses (HBV and HCV, respectively), as well as the human immunodeficiency virus (HIV). Objective: This systemic review aims to assess the prevalence of TTIs in transfusion-dependent β-thalassemia patients in Asia. Methods: The data for the systematic review were gathered from PubMed, Google Scholar, the Directory of Open Access Journals (DOAJ), and ScienceDirect using the following keywords: "prevalence, HBV, HCV, HIV, thalassemia, and transfusion-transmitted infections (TTIs)," and so on. This review includes the research articles that address the prevalence of viral infections in thalassemic patients following blood transfusion. Results: A preliminary search of various databases identified 231 potential studies. 157 duplicate studies were eliminated, and the eligibility of 59 full-length articles was determined. Only 43 studies met the inclusion criteria. Among the 43 studies analyzed, 11 reported a high prevalence of HCV alone in thalassemic patients, while 21 reported a high prevalence of HCV and HBV infection in thalassemic patients. Eight studies reported the prevalence of all three TTIs examined, namely, HCV, HBV, and HIV, in patients with transfusion-dependent thalassemia. Conclusion: Preventable transfusion-transmitted infections occur frequently, and robust national policies and hemovigilance are required to detect and mitigate the infection risk.
Databáze:	MEDLINE
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