| Autor: |
de Paula GA; Department of Pharmacy and Nutrition, Federal University of Espirito Santo, Alegre, ES, Brazil., Costa NN; Graduate Program in Veterinary Sciences. Center of Agricultural and Engineering Sciences, Federal University of Espírito Santo, Alegre, ES, Brazil., da Silva TM; Graduate Program in Veterinary Sciences. Center of Agricultural and Engineering Sciences, Federal University of Espírito Santo, Alegre, ES, Brazil., Bastos KA; Department of Pharmacy and Nutrition, Federal University of Espirito Santo, Alegre, ES, Brazil., Ignacchiti MDC; Department of Pharmacy and Nutrition, Federal University of Espirito Santo, Alegre, ES, Brazil., Severi JA; Department of Pharmacy and Nutrition, Federal University of Espirito Santo, Alegre, ES, Brazil., Oréfice RL; School of Engineering, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Carreira LG; Graduate Program in Veterinary Sciences. Center of Agricultural and Engineering Sciences, Federal University of Espírito Santo, Alegre, ES, Brazil., Villanova JCO; Department of Pharmacy and Nutrition, Federal University of Espirito Santo, Alegre, ES, Brazil.; Graduate Program in Veterinary Sciences. Center of Agricultural and Engineering Sciences, Federal University of Espírito Santo, Alegre, ES, Brazil., Resende JA; Department of Pharmacy and Nutrition, Federal University of Espirito Santo, Alegre, ES, Brazil.; Graduate Program in Veterinary Sciences. Center of Agricultural and Engineering Sciences, Federal University of Espírito Santo, Alegre, ES, Brazil. |
| Abstrakt: |
Polymeric films containing pomegranate peel extract (PPE) can act as a drug-delivery platform for topical treatment of candidiasis. The composition, mechanical resistance, and in vitro antifungal activity of a polymeric film containing PPE at 1.25 mg.mL -1 were investigated. Films were prepared using a solvent casting technique. The incorporation of PPE in the polymeric matrix gave rise to homogeneous, smooth, shiny, and yellowish-brown films. FTIR spectra of the film containing PPE showed differences without compromising the stability of the extract and the matrix. SEM analysis showed the existence of interruptions in the continuity of the films with extract, which promoted a reduction in the mechanical parameters without significantly changing the tensile strength and elongation at break. Films showed adequate mechanical properties and antifungal activity against Candida albicans , C. glabrata , C. krusei and C. tropicalis . |
