Acetylene containing 2-(2-hydrazinyl)thiazole derivatives: design, synthesis, and in vitro and in silico evaluation of antimycobacterial activity against Mycobacterium tuberculosis .
| Autor: | Maganti LHB; Department of Chemistry, Pondicherry University Kalapet Puducherry-605014 India tharani.che@pondiuni.edu.in +91-413-265 6740 +91-413-265 4411., Ramesh D; Department of Chemistry, Pondicherry University Kalapet Puducherry-605014 India tharani.che@pondiuni.edu.in +91-413-265 6740 +91-413-265 4411., Vijayakumar BG; Department of Chemistry, Pondicherry University Kalapet Puducherry-605014 India tharani.che@pondiuni.edu.in +91-413-265 6740 +91-413-265 4411., Khan MIK; Department of Biotechnology, Pondicherry University Kalapet Puducherry-605014 India., Dhayalan A; Department of Biotechnology, Pondicherry University Kalapet Puducherry-605014 India., Kamalraja J; Department of Chemistry, Pondicherry University Kalapet Puducherry-605014 India tharani.che@pondiuni.edu.in +91-413-265 6740 +91-413-265 4411., Kannan T; Department of Chemistry, Pondicherry University Kalapet Puducherry-605014 India tharani.che@pondiuni.edu.in +91-413-265 6740 +91-413-265 4411. |
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| Jazyk: | angličtina |
| Zdroj: | RSC advances [RSC Adv] 2022 Mar 21; Vol. 12 (14), pp. 8771-8782. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022). |
| DOI: | 10.1039/d2ra00928e |
| Abstrakt: | Mycobacterium tuberculosis resistance to commercially available drugs is increasing day by day. To address this issue, various strategies were planned and are being implemented. However, there is a need for new drugs and rapid diagnostic methods. For this endeavour, in this paper, we present the synthesis of acetylene containing 2-(2-hydrazinyl) thiazole derivatives and in vitro evaluation against the H37Rv strain of Mycobacterium tuberculosis . Among the developed 26 acetylene containing 2-(2-hydrazinyl) thiazole derivatives, eight compounds inhibited the growth of Mycobacterium tuberculosis with MIC values ranging from 100 μg ml -1 to 50 μg ml -1 . The parent acetylene containing thiosemicarbazones showed promising antimycobacterial activity by inhibiting up to 75% of the Mycobacterium at 50 μg ml -1 . In addition, in silico studies were employed to understand the binding mode of all the novel acetylene-containing derivatives against the KasA protein of the Mycobacterium . Interestingly, the KasA protein interactions with the compounds were similar to the interactions of KasA protein with thiolactomycin and rifampicin. Cytotoxicity study results indicate that the compounds tested are non-toxic to human embryonic kidney cells. Competing Interests: All the authors confirm that there are no conflicts of interest to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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