Therapeutic Potential of Microvesicles in Cell Therapy and Regenerative Medicine of Ocular Diseases With an Especial Focus on Mesenchymal Stem Cells-Derived Microvesicles.

Autor:	Rad LM; Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran., Yumashev AV; Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russia., Hussen BM; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.; Center of Research and Strategic Studies, Lebanese French University, Kurdistan Region, Erbil, Iraq., Jamad HH; Department of Biology, College of Education, Salahaddin University-Erbil, Kurdistan Region, Erbil, Iraq., Ghafouri-Fard S; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Taheri M; Institute of Human Genetics, Jena University Hospital, Jena, Germany., Rostami S; Department of Immunology, School of Medicine, Zanjan University of Medical Sciecnes, Zanjan, Iran., Niazi V; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hajiesmaeili M; Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Critical Care Quality Improvement Research Center, Loghman Hakin Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Frontiers in genetics [Front Genet] 2022 Mar 29; Vol. 13, pp. 847679. Date of Electronic Publication: 2022 Mar 29 (Print Publication: 2022).
DOI:	10.3389/fgene.2022.847679
Abstrakt:	These days, mesenchymal stem cells (MSCs), because of immunomodulatory and pro-angiogenic abilities, are known as inevitable factors in regenerative medicine and cell therapy in different diseases such as ocular disorder. Moreover, researchers have indicated that exosome possess an essential potential in the therapeutic application of ocular disease. MSC-derived exosome (MSC-DE) have been identified as efficient as MSCs for treatment of eye injuries due to their small size and rapid diffusion all over the eye. MSC-DEs easily transfer their ingredients such as miRNAs, proteins, and cytokines to the inner layer in the eye and increase the reconstruction of the injured area. Furthermore, MSC-DEs deliver their immunomodulatory cargos in inflamed sites and inhibit immune cell migration, resulting in improvement of autoimmune uveitis. Interestingly, therapeutic effects were shown only in animal models that received MSC-DE. In this review, we summarized the therapeutic potential of MSCs and MSC-DE in cell therapy and regenerative medicine of ocular diseases. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Rad, Yumashev, Hussen, Jamad, Ghafouri-Fard, Taheri, Rostami, Niazi and Hajiesmaeili.)
Databáze:	MEDLINE
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