Pharmacokinetics of oxytetracycline long-acting on plasma and semen of beef bulls.

Autor: Romano JE; Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA. Electronic address: juanromano@live.com., Barbarossa A; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy; Health Sciences and Technologies-Interdepartmental Centre for Industrial Research (CIRI-SDV) - University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Pagliuca G; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy; Health Sciences and Technologies-Interdepartmental Centre for Industrial Research (CIRI-SDV) - University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Villadóniga GB; St. Joseph Regional Health Center, Pediatric Services, Bryan, TX, USA., Gazzotti T; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy; Health Sciences and Technologies-Interdepartmental Centre for Industrial Research (CIRI-SDV) - University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Mislei B; AUB-INFA, National Institute of Artificial Insemination, University of Bologna, Cadriano, Bologna, Italy., Zironi E; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy; Health Sciences and Technologies-Interdepartmental Centre for Industrial Research (CIRI-SDV) - University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Mari G; Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy; AUB-INFA, National Institute of Artificial Insemination, University of Bologna, Cadriano, Bologna, Italy.
Jazyk: angličtina
Zdroj: Theriogenology [Theriogenology] 2022 Jul 01; Vol. 186, pp. 21-26. Date of Electronic Publication: 2022 Apr 04.
DOI: 10.1016/j.theriogenology.2022.03.032
Abstrakt: The objectives of this investigation were to evaluate the pharmacokinetic parameters of oxytetracycline long-acting in plasma and seminal plasma after a single administration through either subcutaneous or intramuscular route at 10 mg/kg or 20 mg/kg dose. Four Simmental bulls, healthy and satisfactory potential breeders, were used. The route of administration either subcutaneous or intramuscular did not affect the mean values for 10 mg/kg dose in plasma (1,470 ng/mL vs. 1,330 ng/mL; P = 0.82) or seminal plasma (5,710 ng/mL vs. 5,390 ng/mL; P = 0.88), or for 20 mg/kg dose in plasma (2,540 ng/mL vs. 2,590 ng/mL; P = 0.96) or seminal plasma (25,600 ng/mL vs. 19,400 ng/mL; P = 0.58), respectively. Comparison between the 10 mg/kg and 20 mg/kg doses showed a difference in terms of mean plasma levels (1400 ng/mL vs. 2570 ng/mL; P = 0.07) and mean seminal plasma levels (6,480 ng/mL vs. 26,200 ng/mL; P = 0.004), respectively. After the dose of 10 mg/kg, plasma C max was 2,841 ng/mL at 12 h (T max ) with a half-life of 20.1 h; seminal plasma C max was 11,515 ng/mL at 24 h (T max ) with a half-life of 23.7 h. After the dose of 20 mg/kg, plasma C max was 5,269 ng/mL at 12 h (T max ) with a half-life of 18.1 h; seminal plasma C max was 55,040 ng/mL at 24 h (T max ) with a half-life of 15.7 h. Oxytetracycline long-acting may be an appropriate antibiotic, owing to its pharmacokinetic properties, that could be used for treating bulls' genital infections when its usage is indicated.
Competing Interests: Declaration of competing interest All authors declare that no conflict of interest could be perceived as prejudicing the impartiality of the research reported.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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