Characteristics of human leptospirosis in three different geographical and climatic zones of Vietnam: a hospital-based study.

Autor:	Mai LTP; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam. Electronic address: lepmai08@gmail.com., Dung LP; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Mai TNP; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Hanh NTM; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Than PD; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Tran VD; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Quyet NT; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Hai H; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Ngoc DB; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Hai PT; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Hoa LM; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Thu NT; Hanoi Population and Family Planning Branch, Hanoi, Vietnam., Duong TN; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam., Anh DD; National Institute of Hygiene and Epidemiology, 1 Yersin Str., Hanoi, Vietnam.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2022 Jul; Vol. 120, pp. 113-120. Date of Electronic Publication: 2022 Apr 10.
DOI:	10.1016/j.ijid.2022.04.011
Abstrakt:	Background: To our knowledge, this study is the first report on the seroprevalence of human leptospirosis and its epidemiological profile in 3 different geographical and climatic zones of Vietnam. Methodology: A hospital-based surveillance in 11 public hospitals in 3 provinces in Vietnam enrolled 3,815 patients with suspected leptospirosis. Two consecutive enzyme-linked immunosorbent assay IgM and a single microscopic aggregation test were applied at a 1:100 to 1:800 dilution for probable or confirmed cases. Results: The findings showed that of the 3,815 suspected cases, 68 (1.8%) were Leptospira-confirmed and 248 (6.5%) probable cases, whereas more than a third were positive for acute ELISA-IgM sera. Furthermore, 20 different serovars were found, of which Wolffi (14.2%), Hebdomadis (13.8%), and Icterohaemorrhagiae (12.6%) were the most predominant. The ratio of probable and confirmed cases of leptospirosis between females and males was 1.4:1, and their clinical manifestation was not specific. Cases were more likely to be detected in groups that are farmers, pet raising or livestock farming, of working age, practicing either wading in mud or walking barefoot, or exposed to heavy rainfall. Conclusions: Analysis of human leptospirosis has indicated fairly high seroprevalence and diversity of Leptospira serovars circulating in all studied geographical zones in Vietnam. The findings suggest an imperative need for effective measures of disease prevention, especially in high-risk groups. Competing Interests: Conflict of interest statement The authors declare no conflict of interest. (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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