Endocannabinoid signaling in oligodendroglia.

Autor: Molina-Holgado E; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos (SESCAM), Toledo, Spain., Esteban PF; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos (SESCAM), Toledo, Spain., Arevalo-Martin Á; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos (SESCAM), Toledo, Spain., Moreno-Luna R; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos (SESCAM), Toledo, Spain., Molina-Holgado F; School of Life & Health Sciences, University of Roehampton, Whitelands College, London, UK., Garcia-Ovejero D; Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos (SESCAM), Toledo, Spain.
Jazyk: angličtina
Zdroj: Glia [Glia] 2023 Jan; Vol. 71 (1), pp. 91-102. Date of Electronic Publication: 2022 Apr 12.
DOI: 10.1002/glia.24180
Abstrakt: In the central nervous system, oligodendrocytes synthesize the myelin, a specialized membrane to wrap axons in a discontinuous way allowing a rapid saltatory nerve impulse conduction. Oligodendrocytes express a number of growth factors and neurotransmitters receptors that allow them to sense the environment and interact with neurons and other glial cells. Depending on the cell cycle stage, oligodendrocytes may respond to these signals by regulating their survival, proliferation, migration, and differentiation. Among these signals are the endocannabinoids, lipidic molecules synthesized from phospholipids in the plasma membrane in response to cell activation. Here, we discuss the evidence showing that oligodendrocytes express a full endocannabinoid signaling machinery involved in physiological oligodendrocyte functions that can be therapeutically exploited to promote remyelination in central nervous system pathologies.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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