Signaling pathways and the potential anticarcinogenic effect of native Brazilian fruits on breast cancer.

Autor: Reguengo LM; University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo state, Brazil. Electronic address: l229471@dac.unicamp.br., Nascimento RPD; University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo state, Brazil. Electronic address: roberto_beto1@hotmail.com., Machado APDF; University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo state, Brazil. Electronic address: anapfonsecam@gmail.com., Marostica Junior MR; University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo state, Brazil. Electronic address: mmarosti@unicamp.br.
Jazyk: angličtina
Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2022 May; Vol. 155, pp. 111117. Date of Electronic Publication: 2022 Mar 11.
DOI: 10.1016/j.foodres.2022.111117
Abstrakt: Breast cancer (BC) is the type of cancer with the highest incidence and mortality rates in women worldwide. Despite its well-established risk factors, BC is following an epidemiological pattern, similar to obesity and other western pandemics, associated to demographic and environmental factors. Food and specific bioactive compounds have been evidenced as key factors in BC status attenuation. Native Brazilian fruits and derived products are rich sources of bioactive compounds, which exert valuable antioxidant, anti-inflammatory, and anticancer effects. Therefore, the aim of this review is to evidence the potential of Brazilian fruits in BC by revealing some of the mechanisms underlaying the anticancer effects of their respective bioactive compounds. The interventions investigated here generally show promising evidence, reducing tumor growth or cancer cell viability, and regulating the cell cycle. Native Brazilian fruits, such as açaí, cocoa, guarana, passionfruit, and pineapple have been associated with the regulation of BC-related molecular biomarkers.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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