Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons.

Autor:	Stujenske JM; Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: jmstujenske@gmail.com., O'Neill PK; Department of Psychiatry, Columbia University, New York, NY 10027, USA; The Mortimer B. Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Fernandes-Henriques C; Biology Program, The Graduate Center, City University of New York, New York, NY 10016, USA; Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA., Nahmoud I; Wayne State University School of Medicine, Detroit, MI 48201, USA., Goldburg SR; Department of Ophthalmology, Northwell Health, Great Neck, NY 11021, USA., Singh A; Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA., Diaz L; Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, USA., Labkovich M; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hardin W; Amazon Games, San Diego, CA 92127, USA., Bolkan SS; Princeton Neuroscience Institute, Princeton, New Jersey 08540, USA., Reardon TR; Meta Reality Labs, Redmond, WA 98052, USA., Spellman TJ; Department of Neuroscience, UConn School of Medicine, Farmington, CT 06032, USA., Salzman CD; Department of Psychiatry, Columbia University, New York, NY 10027, USA; The Mortimer B. Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Neuroscience, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Sciences, Columbia University, New York, NY 10027, USA; New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA., Gordon JA; National Institute of Mental Health, Bethesda, MD 20892, USA., Liston C; Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA., Likhtik E; Biology Program, The Graduate Center, City University of New York, New York, NY 10016, USA; Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA. Electronic address: elikhtik@genectr.hunter.cuny.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2022 Jul 20; Vol. 110 (14), pp. 2258-2267.e11. Date of Electronic Publication: 2022 Apr 08.
DOI:	10.1016/j.neuron.2022.03.020
Abstrakt:	The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate discrimination of a non-threatening stimulus is unknown. Here, we show that somatostatin (SOM) interneurons in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues and desynchronize cell firing by blocking phase reset of theta oscillations during the safe cue. Furthermore, we show that SOM activation and desynchronization of the BLA is PL-dependent and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM responses to non-threatening stimuli. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu