Investigation of the Inter- and Intrascanner Reproducibility and Repeatability of Radiomics Features in T1-Weighted Brain MRI.

Autor: Mitchell-Hay RN; Department of Radiology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK., Ahearn TS; Department of Radiology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK., Murray AD; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK., Waiter GD; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2022 Nov; Vol. 56 (5), pp. 1559-1568. Date of Electronic Publication: 2022 Apr 09.
DOI: 10.1002/jmri.28191
Abstrakt: Background: Radiomics is the high throughput analysis of medical images using computer algorithms, which specifically assess textural features. It has increasingly been proposed as a tool for the development of imaging biomarkers. However, an important acknowledged limitation of radiomics is the lack of reproducibility of features produced.
Purpose: To assess reproducibility and repeatability of radiomics variables in brain MRI through a multivisit, multicenter study.
Study Type: Retrospective.
Population: Fourteen individuals visiting three institutions twice, 10 males with the mean age of 36.3 years and age range 25-51.
Field Strength: 3D T1W inversion recovery on three 1.5-T General Electric scanners.
Assessment: Radiomics analysis by a consultant radiologist performed on the T1W images of the whole brain on all visits. All possible radiomics features were generated.
Statistical Test: Concordance correlation coefficient (CCC) and dynamic range (DR) for all variables were calculated to assess the test-retest repeatability. Intraclass correlation coefficients (ICCs) were calculated to investigate the reproducibility of features across centers.
Results: Of 1596 features generated, 57 from center 1, 15 from center 2, and 22 from center 3 had a CCC > 0.9 and DR > 0.9. Eight variables had CCC > 0.9 and DR > 0.9 in all centers. Forty-one variables had an ICC of >0.9. No variables had CCC > 0.9, DR > 0.9, and ICC > 0.9.
Data Conclusion: Repeatability and reproducibility of variables is a significant limitation of radiomics analysis in 3DT1W brain MRI. Careful selection of radiomic features is required.
Level of Evidence: 4 TECHNICAL EFFICACY STAGE: 2.
(© 2022 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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