| Autor: |
Manetta IP; Department of Otolaryngology Pontificia, Universidade Católica de Campinas, - Campinas - São Paulo - Brazil., Ettlin D; University of Zurich, Center of Dental Medicine - Zurich - Zurich - Switzerland.; Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Berne, Berne, Switzerland., Sanz PM; Catholic University of Murcia, Dental Sleep Medicine - Murcia - Murcia - Spain., Rocha I; Cardiovascular Autonomic Function Lab, Centro Cardiovascular da Universidade de Lisboa, Lisbon School of Medicine, Lisbon, Portugal., Meira E Cruz M; Sleep Unit, Centro Cardiovascular da Universidade de Lisboa, Lisbon School of Medicine, Lisbon, Portugal.; Neuroimune Pain Interface Lab, Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil.; International Center of Clinical Sleep Medicine and Research, Escola Bahiana de Medicina e Saúde Pública, Salvador - Bahia, Brazil. |
| Abstrakt: |
Obstructive sleep apnea (OSA) is the most prevalent sleep-disordered breathing in the adult population and if untreated remains a significant cause of morbidity and mortality. Continuous positive airway pressure (CPAP) therapy is still the gold standard treatment for OSA, but patient acceptance and adherence are often poor due to a multitude of factors, thereby compromising treatment success. Mandibular advancement devices (MADs) have been proposed not only as a first line therapy for symptomatic snoring patients, but also for those suffering from mild to moderate OSA, or those who refuse or do not tolerate CPAP. Yet, improved understanding of MAD regarding design, construction, and mechanisms of action is an important requirement to successfully implement MAD as a therapeutic tool. Therefore, the main focus of this paper is to focus on the general concepts and mechanisms of action of MAD, while highlighting important characteristics in the context of their use as a viable and effective treatment option for OSA patients. |
