Methods for induction and assessment of intestinal permeability in rodent models of radiation injury.

Autor:	Ewing LE; Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States., Biju PG; Department of Biochemistry, University of Kerala, Trivandrum, India., Pathak R; Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, United States., Melnyk S; Arkansas Children's Research Institute, Little Rock, AR, United States., Hauer-Jensen M; Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, United States., Koturbash I; Department of Environmental and Occupational Health, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, United States; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR, United States. Electronic address: ikoturbash@uams.edu.
Jazyk:	angličtina
Zdroj:	Methods in cell biology [Methods Cell Biol] 2022; Vol. 168, pp. 235-247. Date of Electronic Publication: 2022 Jan 12.
DOI:	10.1016/bs.mcb.2021.12.017
Abstrakt:	Ionizing radiation (IR) is a significant contributor to the contemporary market of energy production and an important diagnostic and treatment modality. Besides having numerous useful applications, it is also a ubiquitous environmental stressor and a potent genotoxic and epigenotoxic agent, capable of causing substantial damage to organs and tissues of living organisms. The gastrointestinal (GI) tract is highly sensitive to IR. This problem is further compounded by the fact that there is no FDA-approved medication to mitigate acute radiation-induced GI syndrome. Therefore, establishing the animal model for studying IR-induced GI-injury is crucially important to understand the harmful consequences of intestinal radiation damage. Here, we discuss two different animal models of IR-induced acute gastrointestinal syndrome and two separate methods for measuring the magnitude of intestinal radiation damage. (Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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