Cerebellar Transcranial Magnetic Stimulation (TMS) Impairs Visual Working Memory.

Autor: Viñas-Guasch N; Psychology, School of Social Sciences, Nanyang Technological University, Singapore, Singapore., Ng THB; National Institute of Education, Nanyang Technological University, Singapore, Singapore., Heng JG; Psychology, School of Social Sciences, Nanyang Technological University, Singapore, Singapore.; School of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore., Chan YC; Division of Neurology, University Medicine Cluster, National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chew E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Division of Rehabilitation Medicine, Department of Medicine, National University Health System, Singapore, Singapore., Desmond JE; The Johns Hopkins University School of Medicine, Baltimore, USA., Chen SHA; Psychology, School of Social Sciences, Nanyang Technological University, Singapore, Singapore. annabelchen@ntu.edu.sg.; National Institute of Education, Nanyang Technological University, Singapore, Singapore. annabelchen@ntu.edu.sg.; Centre for Research and Development in Learning (CRADLE), Nanyang Technological University, Singapore, Singapore. annabelchen@ntu.edu.sg.; Lee Kong Chian School of Medicine (LKCMedicine), Nanyang Technological University, Singapore, Singapore. annabelchen@ntu.edu.sg.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2023 Jun; Vol. 22 (3), pp. 332-347. Date of Electronic Publication: 2022 Mar 31.
DOI: 10.1007/s12311-022-01396-2
Abstrakt: An increasing body of evidence points to the involvement of the cerebellum in cognition. Specifically, previous studies have shown that the superior and inferior portions of the cerebellum are involved in different verbal working memory (WM) mechanisms as part of two separate cerebro-cerebellar loops for articulatory rehearsal and phonological storage mechanisms. In comparison, our understanding of the involvement of the cerebellum in visual WM remains limited. We have previously shown that performance in verbal WM is disrupted by single-pulse transcranial magnetic stimulation (TMS) of the right superior cerebellum. The present study aimed to expand on this notion by exploring whether the inferior cerebellum is similarly involved in visual WM. Here, we used fMRI-guided, double-pulse TMS to probe the necessity of left superior and left inferior cerebellum in visual WM. We first conducted an fMRI localizer using the Sternberg visual WM task, which yielded targets in left superior and inferior cerebellum. Subsequently, TMS stimulation of these regions at the end of the encoding phase resulted in decreased accuracy in the visual WM task. Differences in the visual WM deficits caused by stimulation of superior and inferior left cerebellum raise the possibility that these regions are involved in different stages of visual WM.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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